The next generation of protein super‐fibres: robust recombinant production and recovery of hagfish intermediate filament proteins with fibre spinning and mechanical–structural characterizations [PDF]
Microbial Biotechnology, 2021 Summary Native hagfish intermediate filament proteins have impressive mechanical properties. However, using these native fibres for any application is impractical, necessitating their recombinant production. In the only literature report on the proteins (
Paula E. Oliveira +8 more
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Mechanical Properties of Intermediate Filament Proteins. [PDF]
Methods Enzymol, 2016 Purified intermediate filament (IF) proteins can be reassembled in vitro to produce polymers closely resembling those found in cells, and these filaments form viscoelastic gels. The cross-links holding IFs together in the network include specific bonds between polypeptides extending from the filament surface and ionic interactions mediated by divalent ...
Charrier EE, Janmey PA.
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Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. [PDF]
PLoS ONE, 2015 Patients with giant axonal neuropathy (GAN) show progressive loss of motor and sensory function starting in childhood and typically live for less than 30 years.
Bethany L Johnson-Kerner +3 more
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Desmoplakin interacts with the coil 1 of different types of intermediate filament proteins and displays high affinity for assembled intermediate filaments. [PDF]
PLoS ONE, 2018 The interaction of intermediate filaments (IFs) with the cell-cell adhesion complexes desmosomes is crucial for cytoskeletal organization and cell resilience in the epidermis and heart.
Bertrand Favre +6 more
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Nootkatone Counteracts Melamine-Mediated Nephrotoxicity via Modulation of Intermediate Filament Proteins, Oxidative, Inflammatory, and Apoptotic Events [PDF]
Drug Design, Development and TherapyDoaa Abdelrahaman,1 Ola A Habotta,2 Ahmed Ateya,3 Ahmed A Aldarmahi,4,5 Reham A El-Shafei,6 Mohamed M Badawy,7,8 Ahmed A El-Mansy,9,10 Thoraya M A-Elgadir,11 Aml M Nada,12 Mona G Elhadidy,13,14 Eman Hamza,15,16 Khairiah M Alwutayed,17 Mohamed El-Sherbiny,
Abdelrahaman D +15 more
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Post-translational modifications of intermediate filament proteins: mechanisms and functions [PDF]
Nature Reviews Molecular Cell Biology, 2014 , Bishr Omary, Omary M Bishr
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Engineered Recombinant Hagfish Intermediate Filament Proteins: Unraveling Domain Roles in Synthetic Fiber Formation and Mechanics [PDF]
ACS OmegaOran Wasserman +7 more
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Tailorable Hydrogel Fibers from High-Yield Recombinant Hagfish Intermediate Filament Proteins: A New Frontier in Biomimetic Materials [PDF]
ACS OmegaBrianne E. Bell +5 more
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Trypanosoma cruzi Binds to Cytokeratin through Conserved Peptide Motifs Found in the Laminin-G-Like Domain of the gp85/Trans-sialidase Proteins. [PDF]
PLoS Neglected Tropical Diseases, 2015 BACKGROUND:Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, is a disease that affects millions of people most of them living in South and Central Americas. There are few treatment options for individuals with Chagas' disease making it
Andre Azevedo Reis Teixeira +4 more
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Intermediate Filament Protein Partnership in Astrocytes [PDF]
Journal of Biological Chemistry, 1999 Intermediate filaments are general constituents of the cytoskeleton. The function of these structures and the requirement for different types of intermediate filament proteins by individual cells are only partly understood. Here we have addressed the role of specific intermediate filament protein partnerships in the formation of intermediate filaments ...
C, Eliasson +7 more
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