Results 31 to 40 of about 2,434,460 (293)

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength [PDF]

, 2002
By tethering intermediate filaments (IFs) to sites of intercellular adhesion, desmosomes facilitate formation of a supercellular scaffold that imparts mechanical strength to a tissue.
Godsel, Lisa M., Hudson, TY, Green, Kathleen J., Kathleen J. Green, Gumbiner, BM, Hudson, Tracie Y., Kelsell, David P., Leigh, IM, Leigh, Irene M., Evangeline V. Amargo, Anne K. Mongiu, Huen, Arthur C., Leslie J. Bannon, Bannon, Leslie J., Mongiu, AK, David P. Kelsell, Kelsell, DP, Park, Jung K., Park, JK, Green, KJ, Huen, AC, Chen, XJ, Xuejun Chen, Bannon, LJ, Arthur C. Huen, Amargo, Evangeline V., Gumbiner, Barry M., Chen, Xuejun, Tracie Y. Hudson, Irene M. Leigh, Lisa M. Godsel, Barry M. Gumbiner, Mongiu, Anne K., Jung K. Park, Amargo, FV, Godsel, LM   +35 more
core   +1 more source

Intermediate Filaments and Polarization in the Intestinal Epithelium

Cells, 2016
The cytoplasmic intermediate filament cytoskeleton provides a tissue-specific three-dimensional scaffolding with unique context-dependent organizational features.
Richard A. Coch, Rudolf E. Leube
doaj   +1 more source

Order and disorder in intermediate filament proteins [PDF]

FEBS Letters, 2015
Intermediate filaments (IFs), important components of the cytoskeleton, provide a versatile, tunable network of self‐assembled proteins. IF proteins contain three distinct domains: an α‐helical structured rod domain, flanked by intrinsically disordered head and tail domains.
Kornreich, Micha, Avinery, Ram, Malka-Gibor, Eti, Laser-Azogui, Adi, Beck, Roy   +4 more
openaire   +2 more sources

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications. [PDF]

J Vis Exp, 2017
In this method we present biochemical procedures for rapid and efficient isolation of intermediate filament (IF) proteins from multiple mouse tissues. Isolated IFs can be used to study changes in post-translational modifications by mass spectrometry and ...
Battaglia RA, Kabiraj P, Willcockson HH, Lian M, Snider NT.   +4 more
europepmc   +2 more sources

Desmin Reorganization by Stimuli Inducing Oxidative Stress and Electrophiles: Role of Its Single Cysteine Residue

Antioxidants, 2023
The type III intermediate filament proteins vimentin and GFAP are modulated by oxidants and electrophiles, mainly through perturbation of their single cysteine residues.
Diego Moneo-Corcuera, Álvaro Viedma-Poyatos, Konstantinos Stamatakis, Dolores Pérez-Sala   +3 more
doaj   +1 more source

Coil 2 of intermediate filaments: its complete structure and impact of desminopathy-related mutations. [PDF]

, 2011
The eukaryotic cytoskeleton consists of three major filamentous networks. The thinnest filament network of about 6 nm diameter is made up of globular actin subunits, whereas the thicker microtubule network of about 22 nm diameter contains 13 ...
Nicolet, Stefan
core   +1 more source

Epithelial Intermediate Filaments: Guardians against Microbial Infection?

Cells, 2016
Intermediate filaments are abundant cytoskeletal components of epithelial tissues. They have been implicated in overall stress protection. A hitherto poorly investigated area of research is the function of intermediate filaments as a barrier to microbial
Florian Geisler, Rudolf E. Leube
doaj   +1 more source

BM-MSCs alleviate diabetic nephropathy in male rats by regulating ER stress, oxidative stress, inflammation, and apoptotic pathways

Frontiers in Pharmacology, 2023
Introduction: Diabetic nephropathy (DN), a chronic kidney disease, is a major cause of end-stage kidney disease worldwide. Mesenchymal stem cells (MSCs) have become a promising option to mitigate several diabetic complications.Methods: In this study, we ...
Tarek Khamis, Adel Abdelkhalek, Hussein Abdellatif, Hussein Abdellatif, Nourelden Dwidar, Ahmed Said, Rama Ahmed, Kerolos Wagdy, Rowina Elgarhy, Rawan Eltahan, Hisham Mohamed, Eman Said Amer, Maria Hanna, Tarek Ragab, Abdallah Kishk, Judy Wael, Eyad Sarhan, Linda Saweres, Mohamed Reda, Sara Elkomy, Abdalah Mohamed, Abdullah Samy, Ateya Khafaga, Youliana Shaker, Hamdy Yehia, Asma Alanazi, Asma Alanazi, Mohammed Alassiri, Mohammed Alassiri, Mohammed Alassiri, Emil Tîrziu, Iulia Maria Bucur, Ahmed Hamed Arisha, Ahmed Hamed Arisha   +33 more
doaj   +1 more source

Expression of chicken lamin B2 in Escherichia coli : characterization of its structure, assembly, and molecular interactions [PDF]

, 1991
Chicken lamin B2, a nuclear member of the intermediate-type filament (IF) protein family, was expressed as a full-length protein in Escherichia coli.
Aebi, U., Peter, M., Lustig, A., E Heitlinger, M Häner, M Peter, Häner, M., Nigg, E. A., U Aebi, Heitlinger, E., A Lustig, E A Nigg   +11 more
core   +1 more source

Role of the gp85/trans-sialidases in Trypanosoma cruzi tissue tropism: preferential binding of a conserved peptide motif to the vasculature in vivo. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: Transmitted by blood-sucking insects, the unicellular parasite Trypanosoma cruzi is the causative agent of Chagas' disease, a malady manifested in a variety of symptoms from heart disease to digestive and urinary tract dysfunctions.
Renata R Tonelli, Ricardo J Giordano, Elena Magda Barbu, Ana Claudia Torrecilhas, Gerson S Kobayashi, Robert R Langley, Wadih Arap, Renata Pasqualini, Walter Colli, Maria Júlia M Alves   +9 more
doaj   +1 more source