Results 21 to 30 of about 57,839 (257)

BM-MSCs alleviate diabetic nephropathy in male rats by regulating ER stress, oxidative stress, inflammation, and apoptotic pathways

Frontiers in Pharmacology, 2023
Introduction: Diabetic nephropathy (DN), a chronic kidney disease, is a major cause of end-stage kidney disease worldwide. Mesenchymal stem cells (MSCs) have become a promising option to mitigate several diabetic complications.Methods: In this study, we ...
Tarek Khamis, Adel Abdelkhalek, Hussein Abdellatif, Hussein Abdellatif, Nourelden Dwidar, Ahmed Said, Rama Ahmed, Kerolos Wagdy, Rowina Elgarhy, Rawan Eltahan, Hisham Mohamed, Eman Said Amer, Maria Hanna, Tarek Ragab, Abdallah Kishk, Judy Wael, Eyad Sarhan, Linda Saweres, Mohamed Reda, Sara Elkomy, Abdalah Mohamed, Abdullah Samy, Ateya Khafaga, Youliana Shaker, Hamdy Yehia, Asma Alanazi, Asma Alanazi, Mohammed Alassiri, Mohammed Alassiri, Mohammed Alassiri, Emil Tîrziu, Iulia Maria Bucur, Ahmed Hamed Arisha, Ahmed Hamed Arisha   +33 more
doaj   +1 more source

Desmin Reorganization by Stimuli Inducing Oxidative Stress and Electrophiles: Role of Its Single Cysteine Residue

Antioxidants, 2023
The type III intermediate filament proteins vimentin and GFAP are modulated by oxidants and electrophiles, mainly through perturbation of their single cysteine residues.
Diego Moneo-Corcuera, Álvaro Viedma-Poyatos, Konstantinos Stamatakis, Dolores Pérez-Sala   +3 more
doaj   +1 more source

Role of the gp85/trans-sialidases in Trypanosoma cruzi tissue tropism: preferential binding of a conserved peptide motif to the vasculature in vivo. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: Transmitted by blood-sucking insects, the unicellular parasite Trypanosoma cruzi is the causative agent of Chagas' disease, a malady manifested in a variety of symptoms from heart disease to digestive and urinary tract dysfunctions.
Renata R Tonelli, Ricardo J Giordano, Elena Magda Barbu, Ana Claudia Torrecilhas, Gerson S Kobayashi, Robert R Langley, Wadih Arap, Renata Pasqualini, Walter Colli, Maria Júlia M Alves   +9 more
doaj   +1 more source

Immunohistochemical expression of intermediate filaments in diagnostics of diffuse gliomas.

Medičnì Perspektivi, 2017
Intermediate filament proteins play an important role in maintaining a stable shape, as well as the possible movement of cells, including neoplastic cells.
T. V. Shynkarenko
doaj   +1 more source

Keratin 76 is required for tight junction function and maintenance of the skin barrier. [PDF]

PLoS Genetics, 2014
Keratins are cytoskeletal intermediate filament proteins that are increasingly being recognised for their diverse cellular functions. Here we report the consequences of germ line inactivation of Keratin 76 (Krt76) in mice.
Tia DiTommaso, Denny L Cottle, Helen B Pearson, Holger Schlüter, Pritinder Kaur, Patrick O Humbert, Ian M Smyth   +6 more
doaj   +1 more source

Role of Intermediate Filaments in Blood–Brain Barrier in Health and Disease

Cells, 2021
The blood–brain barrier (BBB) is a highly selective cellular monolayer unique to the microvasculature of the central nervous system (CNS), and it mediates the communication of the CNS with the rest of the body by regulating the passage of molecules into ...
Ece Bayir, Aylin Sendemir
doaj   +1 more source

Order and disorder in intermediate filament proteins [PDF]

FEBS Letters, 2015
Intermediate filaments (IFs), important components of the cytoskeleton, provide a versatile, tunable network of self‐assembled proteins. IF proteins contain three distinct domains: an α‐helical structured rod domain, flanked by intrinsically disordered head and tail domains.
Kornreich, Micha, Avinery, Ram, Malka-Gibor, Eti, Laser-Azogui, Adi, Beck, Roy   +4 more
openaire   +2 more sources

Intermediate filament-co-localized molecules with myosin heavy chain epitopes define distinct cellular domains in hair follicles and epidermis

BMC Cell Biology, 2003
Background Proteins linking intermediate filaments to other cytoskeletal components have important functions in maintaining tissue integrity and cell shape.
Hughes Simon M, Ehler Elisabeth, Jazwinska Ania   +2 more
doaj   +1 more source

Trichinella britovi muscle larvae and adult worms: stage-specific and common antigens detected by two-dimensional gel electrophoresis-based immunoblotting

Parasites & Vectors, 2018
Background Trichinella britovi is the second most common species of Trichinella that may affect human health. As an early diagnosis of trichinellosis is crucial for effective treatment, it is important to identify sensitive, specific and common antigens ...
Sylwia Grzelak, Bożena Moskwa, Justyna Bień   +2 more
doaj   +1 more source

Role of beta1-adrenergic Blockade in Alleviation of Clozapine-induced Cardiotoxic effect in rats via modulation of cardiac cell death, macrophages, and gap junction intercellular communication proteins

SVU - International Journal of Medical Sciences
Background: Clozapine (CLZ) is an effective choice for the treatment of resistant schizophrenia; however, there is a risk of clozapine-induced cardiotoxicity.
Hala M ElBadre, Manal M Kamal* , Basel A Abdel-Wahab , et all.   +3 more
doaj   +1 more source