Capturing intermediate filament networks [PDF]
eLife, 2022 Mapping intermediate filaments in three dimensions reveals that the organization of these filaments differs across cell types.
Pierre A Coulombe
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Molecular Interactions Driving Intermediate Filament Assembly [PDF]
Cells, 2021 Given the role of intermediate filaments (IFs) in normal cell physiology and scores of IF-linked diseases, the importance of understanding their molecular structure is beyond doubt. Research into the IF structure was initiated more than 30 years ago, and
Pieter-Jan Vermeire +6 more
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Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions [PDF]
eLife, 2023 Intermediate filaments (IFs) are major components of the metazoan cytoskeleton. A long-standing debate concerns the question whether IF network organization only reflects or also determines cell and tissue function.
Florian Geisler +5 more
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Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter [PDF]
Cells, 2021 This essay focuses on the role of plectin and its various isoforms in mediating intermediate filament (IF) network functions. It is based on previous studies that provided comprehensive evidence for a concept where plectin acts as an IF recruiter, and ...
Gerhard Wiche
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Intermediate Filament Protein BFSP2 Controls Spindle Formation via HSC70‐Mediated Stabilization of CLTC During Oocyte meiosis [PDF]
Advanced ScienceAs a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis.
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
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Case Report: Pediatric Hallucinations and Anti-Neuronal Intermediate Filament Autoimmune Encephalitis [PDF]
Clinical Practice and Cases in Emergency MedicineIntroduction: Patients with psychiatric concerns often present to an emergency department (ED) for medical evaluation prior to inpatient psychiatry placement. One diagnosis to consider prior to disposition is autoimmune encephalitis (AIE).
Amanda H. Bjornstad +4 more
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Negative tension controls stability and structure of intermediate filament networks [PDF]
Scientific Reports, 2022 Networks, whose junctions are free to move along the edges, such as two-dimensional soap froths and membrane tubular networks of endoplasmic reticulum are intrinsically unstable.
Ehud Haimov +2 more
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Current Biology, 2021 Cell morphology, architecture and dynamics primarily rely on intracellular cytoskeletal networks, which in metazoans are mainly composed of actin microfilaments, microtubules and intermediate filaments (IFs). The diameter size of 10 nm - intermediate between the diameters of actin microfilaments and microtubules - initially gave IFs their name. However,
Dutour-Provenzano, Gaëlle +1 more
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Plasticity of intermediate filament subunits. [PDF]
PLoS ONE, 2010 Intermediate filaments (IFs) assembled in vitro from recombinantly expressed proteins have a diameter of 8-12 nm and can reach several micrometers in length. IFs assemble from a soluble pool of subunits, tetramers in the case of vimentin.
Robert Kirmse +5 more
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The intermediate filament network in cultured human keratinocytes is remarkably extensible and resilient. [PDF]
PLoS ONE, 2008 The prevailing model of the mechanical function of intermediate filaments in cells assumes that these 10 nm diameter filaments make up networks that behave as entropic gels, with individual intermediate filaments never experiencing direct loading in ...
Douglas Fudge +5 more
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