Results 41 to 50 of about 164,981 (291)

Nonlinear Elasticity in Biological Gels [PDF]

, 2004
Unlike most synthetic materials, biological materials often stiffen as they are deformed. This nonlinear elastic response, critical for the physiological function of some tissues, has been documented since at least the 19th century, but the molecular ...
AD Karakaplan, AY Grosberg, Cornelis Storm, D Morse, DA Head, F Gittes, F Gittes, F MacKintosh, F. C. MacKintosh, J Marko, J Wilhelm, J Wilhelm, J Xu, Jennifer J. Pastore, JF Leterrier, JO Hjortdal, JV Shah, K Kroy, L Ma, LD Landau, LD Landau, LRG Treloar, LZ Wang, M Fixman, ML Gardel, PA Janmey, PA Janmey, PA Janmey, PA Janmey, Paul A. Janmey, RE Shadwick, SB Smith, T. C. Lubensky, Y Fung   +33 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Molecular evolution of type VI intermediate filament proteins

BMC Evolutionary Biology, 2007
Background Tanabin, transitin and nestin are type VI intermediate filament (IF) proteins that are developmentally regulated in frogs, birds and mammals, respectively.
Vincent Michel, Savard Pierre E, Khan Paul A, Guérette Dominique   +3 more
doaj   +1 more source

Contrasting expression of keratins in mouse and human embryonic stem cells. [PDF]

PLoS ONE, 2008
RNA expression data reveals that human embryonic stem (hES) cells differ from mouse ES (mES) cells in the expression of RNAs for keratin intermediate filament proteins.
Jochen Maurer, Brandon Nelson, Grace Ceceña, Ruchi Bajpai, Mark Mercola, Alexey Terskikh, Robert G Oshima   +6 more
doaj   +1 more source

Star Formation in the Trifid Nebula [PDF]

, 2008
We have obtained maps of the 1.25mm thermal dust emission and the molecular gas emission over a region of 20' by 10' arcmin around the Trifid Nebula (M20), with the IRAM 30m and the CSO telescopes as well as in the mid-infrared wavelength with ISO and ...
Cernicharo, J., Lefloch, B., Pardo, J. R.   +2 more
core   +5 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Intermediate filament-co-localized molecules with myosin heavy chain epitopes define distinct cellular domains in hair follicles and epidermis

BMC Cell Biology, 2003
Background Proteins linking intermediate filaments to other cytoskeletal components have important functions in maintaining tissue integrity and cell shape.
Hughes Simon M, Ehler Elisabeth, Jazwinska Ania   +2 more
doaj   +1 more source

Conformations of confined biopolymers [PDF]

, 2007
Nanoscale and microscale confinement of biopolymers naturally occurs in cells and has been recently achieved in artificial structures designed for nanotechnological applications.
Erwin Frey, Frederik Wagner, Gianluca Lattanzi, J. A. Aronovitz, L. D. Landau, N. Saitô, P.-G. de Gennes   +6 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A tailored fit: How intermediate filaments orchestrate glioblastoma invasion

Mechanobiology in Medicine
Glioblastoma (GBM) is a highly invasive tumour. Invasion of GBM cells into the densely packed brain parenchyma reflects a profound mechanobiological adaptation to the mechanical constraints of the brain. A recent study by van Bodegraven et al.
Jessy V. van Asperen, Elly M. Hol
doaj   +1 more source