The Discovery and Function of Filaggrin [PDF]
, 2022 Keratohyalin granules were discovered in the mid-19th century in cells that terminally differentiate to form the outer, cornified layer of the epidermis.
Laura L. Eggink, J. Kenneth Hoober
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Proteomic Analysis of Urine to Identify Breast Cancer Biomarker Candidates Using a Label-Free LC-MS/MS Approach. [PDF]
PLoS ONE, 2015 Breast cancer is a complex heterogeneous disease and is a leading cause of death in women. Early diagnosis and monitoring progression of breast cancer are important for improving prognosis.
Julia Beretov +5 more
doaj +1 more source
Differences in Behavior between Normal and Atopic Keratinocytes in Culture: Pilot Studies
Veterinary Sciences, 2022 Skin barrier dysfunction is important in atopic dermatitis and can be secondary to inflammation. Observation of keratinocytes in culture may show intrinsic differences. TransEpithelial Electrical Resistance (TEER) measures epithelial permeability.
Rosanna Marsella +2 more
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Latex allergy and filaggrin null mutations [PDF]
, 2011 Objectives Natural rubber latex (NRL) contains over 200 proteins of which 13 have been identified as allergens and the cause of type I latex allergy. Health care workers share a high occupational risk for developing latex allergy.
Hamann, Quinlan +17 more
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Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin [PDF]
Journal of Histochemistry & Cytochemistry, 2018 Filaggrin (FLG) and corneodesmosin (CDSN) are two key proteins of the human epidermis. FLG loss-of-function mutations are the strongest genetic risk factors for human atopic dermatitis. Studies of the epidermal distribution of canine FLG and CDSN are limited. Our aim was to better characterize the distribution of FLG and CDSN in canine skin.
Pin, Didier +9 more
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GP37 Is Different From Filaggrin [PDF]
, 1990 The identity of two differentiation markers of human epidermis, filaggrin and a Concanavalin A (Con-A) reactive glycoprotein of 37 kD, has been studied. Human epidermis was extracted in Nonidet P-40 buffer, and the soluble proteins were separated by two ...
Sarret, Yves +2 more
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Frontiers in Immunology, 2021 Atopic dermatitis (AD) is a chronic relapsing pruritic disease encompassing skin inflammation and barrier dysfunction. House dust mites are key allergens that augment the development of atopic dermatitis.
Hyang Jeon +9 more
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Genomic, Epigenomic, Transcriptomic, Proteomic and Metabolomic Approaches in Atopic Dermatitis
Current Issues in Molecular Biology, 2023 Atopic dermatitis (AD) is a chronic inflammatory skin disease with a high prevalence in the developed countries. It is associated with atopic and non-atopic diseases, and its close correlation with atopic comorbidities has been genetically demonstrated ...
Dalia Bratu +2 more
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Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization [PDF]
, 2023 PURPOSE. Scleritis is a severe inflammatory ocular disorder with unknown pathogenesis. We investigated healthy sclera as well as sclera affected by noninfectious scleritis for differentially expressed proteins using a mass spectrometry approach. METHODS.
Berge, J.C.T. +23 more
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Crossing Barriers; Restoring Barriers? Filaggrin Protein Replacement Takes a Bow [PDF]
Journal of Investigative Dermatology, 2014 In this issue of the Journal, Stout and colleagues report a novel and creative approach to replacement of genetically determined absence or deficiency of epidermal proteins. While these early data are certainly interesting, further validation work is required to determine the utility of this approach in genodermatoses.
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