Results 11 to 20 of about 7,455 (218)

Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus [PDF]

Journal of Allergy and Clinical Immunology, 2010
Colonization of the skin by Staphylococcus aureus in individuals with atopic dermatitis exacerbates inflammation. Atopic dermatitis is associated with loss-of-function mutations in the filaggrin (FLG) gene, accompanied by reduced levels of filaggrin breakdown products on the skin.To assess the affect of growth in the presence of the filaggrin breakdown
Miajlovic, Helen, Fallon, Padraic G., Irvine, Alan D., Foster, Timothy J.   +3 more
openaire   +5 more sources

Characterization of Two Monoclonal Antibodies to Human Epidermal Keratohyalin: Reactivity With Filaggrin and Related Proteins [PDF]

Journal of Investigative Dermatology, 1987
Two monoclonal antibodies (AKH1 and AKH2) were elicited with partially purified human filaggrin and characterized by immunohistochemistry on normal and abnormal skin biopsies, immunoblotting techniques, and antigen purification. Both antibodies react strongly with the granular cell layer consistent with the distribution of keratohyalin and show a more ...
Dale, Beverly A, Gown, Allen M, Fleckman, Philip, Kimball, Janet R, Resing, Katheryn A   +4 more
openaire   +3 more sources

Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown [PDF]

Journal of Dermatological Science, 2017
Deimination (also known as citrullination), the conversion of arginine in a protein to citrulline, is catalyzed by a family of enzymes called peptidylarginine deiminases (PADs). Three PADs are expressed in the epidermis, one of their targets being filaggrin.
Cau, Laura, Pendaries, Valérie, Lhuillier, Emeline, Thompson, Paul, Serre, Guy, Takahara, Hidenari, Mechin, Marie-Claire, Simon, Michel   +7 more
core   +8 more sources

Tuning the Cell-Free Protein Synthesis System for Biomanufacturing of Monomeric Human Filaggrin [PDF]

Frontiers in Bioengineering and Biotechnology, 2020
The modern cell-free protein synthesis (CFPS) system is expanding the opportunity of cell-free biomanufacturing as a versatile platform for synthesizing various therapeutic proteins.
Jeehye Kim, Caroline E. Copeland, Kosuke Seki, Kosuke Seki, Bastian Vögeli, Yong-Chan Kwon, Yong-Chan Kwon   +6 more
doaj   +3 more sources

A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study [PDF]

BMJ Open, 2011
Background Filaggrin proteins are located in the skin and prevent epidermal water loss and impede the entry of micro-organisms, allergens and chemicals.
Allan Linneberg, Torben Hansen, Jacob P Thyssen, Steen Stender, Oluf Pedersen, Berit C Carlsen, Jeanne D Johansen, Kåre Engkilde, Flemming Pociot, Michael Meldgaard, Pal B Szecsi, Torkil Menné   +11 more
doaj   +2 more sources

Knock-down of filaggrin influences the mitogen-activated protein kinases signaling pathway in normal human epidermal keratinocytes [PDF]

médecine/sciences, 2018
Background: Filaggrin is an essential structural protein of the stratum corneum binding to the keratin intermediate filaments to form a dense protein-lipid matrix. However, the function of filaggrin in epidermal terminal differentiation is not completely understood.
Shumei, Wang, Liyun, Qiu, Xianguang, Meng, Ningning, Dang   +3 more
openaire   +4 more sources

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model [version 2; peer review: 3 approved] [PDF]

Wellcome Open Research, 2019
Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads
Martina S. Elias, Sheila C. Wright, William V. Nicholson, Kimberley D. Morrison, Alan R. Prescott, Sara Ten Have, Phillip D. Whitfield, Angus I. Lamond, Sara J. Brown   +8 more
doaj   +3 more sources

Update on canine filaggrin: a review [PDF]

Veterinary Quarterly, 2020
Human filaggrin (FLG) plays a key role in epidermal barrier function, and loss-of-function mutations of its gene are primarily responsible for the development of human atopic dermatitis (AD).
Daniel Combarros, Marie-Christine Cadiergues, Michel Simon   +2 more
doaj   +2 more sources

Barrier proteins and eosinophilic esophagitis in children: the role of E-cadherin and filaggrin

Allergologia et Immunopathologia, 2022
This study aimed to assess the protein expression of E-cadherin and filaggrin (FLG) in the oesophagus of paediatric and adolescent patients diagnosed with eosinophilic esophagitis (EoE). It is a cross-sectional study conducted with 24 patients with EoE and 17 control patients, from June 2015 to June 2018.
Erica Rezende, Mariza Faria, Ignez Candelori, Juliana S Daud, Flavia A Alves, Jair Cunha Junior, Gesmar Silva Segundo   +6 more
openaire   +2 more sources

1-Iodohexadecane Alleviates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice: Possible Involvements of the Skin Barrier and Mast Cell SNARE Proteins

Molecules, 2022
Atopic dermatitis (AD) is a chronic inflammatory dermal disease with symptoms that include inflammation, itching, and dry skin. 1-Iodohexadecane is known as a component of Chrysanthemum boreale essential oil that has an inhibitory effect on AD-like ...
Do Yoon Kim, Kyung-Jong Won, Dae Il Hwang, Nan Young Kim, Bokyung Kim, Hwan Myung Lee   +5 more
doaj   +1 more source