Results 21 to 30 of about 7,455 (218)

THE ROLE OF GENETIC POLYMORPHISM OF THE FILAGGRIN PROTEIN WITH ATOPIC MARCH PROGRESSION IN CHILDREN

InterConf, 2021
The aim of the study. To determine the role of genetic polymorphism in the filaggrin gene R501XAA and 2282de4AA at atopic march progression in children. Materials and methods. 111 children aged 3 to 12 years with atopic dermatitis were selected and examined.
Stoieva, T. V., Reshetilo, O. V., Vesilyk, N. L., Portnova, O. O., Fedin, M. V., Larionov, O. P.   +5 more
openaire   +2 more sources

Human filaggrin monomer does not seem to be a proteasome target [PDF]

, 2023
International audienceAbsence of a functional proteasome in the suprabasal layers of the epidermis is responsible for keratosis linearis with ichthyosis congenital and sclerosing keratoderma syndrome.
Dominique Bernard, Eric Arbey, Méchin, Marie‐claire, Bernard, Dominique, Julie Briot, Briot, Julie, Dominique Goudounèche, Arbey, Eric, Michel Simon, Simon, Michel, Marie‐Claire Méchin, Goudounèche, Dominique   +11 more
core   +1 more source

Associations of filaggrin gene loss-of-function variants and human papillomavirus-related cancer and pre-cancer in Danish adults. [PDF]

PLoS ONE, 2014
Filaggrin proteins are expressed in the skin, oral cavity, oesophagus, and cervical mucose. Loss-of-function mutations in the filaggrin gene (FLG) reduce filaggrin expression and cause an impaired skin barrier function.
Tea Skaaby, Lise Lotte N Husemoen, Torben Jørgensen, Jeanne D Johansen, Torkil Menné, Pal B Szecsi, Steen Stender, Peter Bager, Jacob P Thyssen, Allan Linneberg   +9 more
doaj   +1 more source

Physicochemical study of a synthetic peptide belonging to human filaggrin protein [PDF]

Le Journal de Physique IV, 2001
In the present work the physicochemical characterization of the (306-324) synthetic peptide sequence from human fiiaggrin protein and its palmitoilated derivative was carried out. Monomolecular layers of dipalmitoilphosphatidilcholine (DPPC) were used to study lipidtpeptide interactions.
T. Pérez, M. Muñoz, Y. Jaouher, M. A. Alsina, I. Haro   +4 more
openaire   +1 more source

Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families [PDF]

, 2008
Recent studies have identified 2 loss-of-function variants, R501X and 2282del4, in the filaggrin gene as predisposing factors in the development of eczema.
Link, Jenny, Lee, Simon P., Lieden, Agne, M D'Amato, Ekelund, Elisabeth, Kockum, Ingrid, SP Lee, D'Amato, Mauro, I Kockum, CNA Palmer, Bradley, Maria, A Liedén, E Ekelund, J Link, M Bradley, Palmer, Colin N. A.; id_orcid   +15 more
core   +1 more source

Peanut allergy:effect of environmental peanut exposure in children with filaggrin loss-of-function mutations [PDF]

, 2014
BackgroundFilaggrin (FLG) loss-of-function mutations lead to an impaired skin barrier associated with peanut allergy. Household peanut consumption is associated with peanut allergy, and peanut allergen in household dust correlates with household peanut ...
Makinson, Kerry, Hankinson, Jenny, Brown, Sara, Adnan Custovic, Nicolaos Nicolaou, McLean, W.H. Irwin, Simpson, Angela, Stephens, Alick C, Nicolaou, Nicolaos, Abdel Douiri, Simpson, Angela; id_orcid, Belgrave, Danielle C M, Kerry Makinson, Helen A. Brough, McLean, W. H. Irwin, Stephens, Alick C., Sara Brown, Brough, Helen A., Alick C. Stephens, Penagos, Martin, Turcanu, Victor, Danielle C.M. Belgrave, Lack, Gideon, Victor Turcanu, Custovic, Adnan, Belgrave, Danielle C. M., Martin Penagos, Jenny Hankinson, Gideon Lack, W.H. Irwin McLean, Brough, Helen A.; id_orcid, Belgrave, Danielle C.M., Douiri, Abdel; id_orcid, McLean, W H Irwin, Douiri, Abdel, Brough, Helen A, Angela Simpson   +36 more
core   +1 more source

Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula

Journal of Traditional Chinese Medical Sciences, 2021
Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis (AD).
Jingang Liu, Yan Sun, Huimin Yuan, Yuda Li, Jing Feng, Yushan Gao, Yang Tang, Shujing Zhang, Hang Wang, Fengjie Zheng   +9 more
doaj   +1 more source

Primary structure of chimeric citrullinated peptides derived from fibrin, filaggrin, vimentin and enolase proteins. [PDF]

, 2019
Primary structure of chimeric citrullinated peptides derived from fibrin, filaggrin, vimentin and enolase proteins.
Cristina García-Moreno (6659672), Isabel Haro (2148178), Raimon Sanmartí (368935), María José Bleda (6659678), María José Gómara (6659675)   +4 more
core   +1 more source

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy [PDF]

, 2015
BACKGROUND: History and severity of atopic dermatitis (AD) are risk factors for peanut allergy. Recent evidence suggests that children can become sensitized to food allergens through an impaired skin barrier.
Sicherer, Scott, Brough, Helen A., Makinson, Kerry, Burks, Wesley, Turcanu, Victor, Jones, Stacie M., Liu, Andrew H., Lack, Gideon, Brown, Sara J., Sampson, Hugh, Wood, Robert A., Douiri, Abdel; id_orcid, Stablein, Donald, Dawson, Peter, Douiri, Abdel, McLean, W. H. Irwin, Stephens, Alick C., Irwin McLean, W.H.   +17 more
core   +1 more source

Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences

Frontiers in Molecular Biosciences, 2022
Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel.
Ewa Izabela Podobas, Ewa Izabela Podobas, Ewa Izabela Podobas, Danuta Gutowska-Owsiak, Danuta Gutowska-Owsiak, Sébastien Moretti, Jarosław Poznański, Mariusz Kulińczak, Marcin Grynberg, Aleksandra Gruca, Arkadiusz Bonna, Dawid Płonka, Tomasz Frączyk, Graham Ogg, Wojciech Bal   +14 more
doaj   +1 more source