Results 21 to 30 of about 6,491,911 (254)

Knock-down of filaggrin influences the mitogen-activated protein kinases signaling pathway in normal human epidermal keratinocytes. [PDF]

médecine/sciences, 2018
BACKGROUND Filaggrin is an essential structural protein of the stratum corneum binding to the keratin intermediate filaments to form a dense protein-lipid matrix.
Shumei Wang, Liyun Qiu, Xianguang Meng, N. Dang   +3 more
semanticscholar   +3 more sources

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response [PDF]

Brazilian Journal of Medical and Biological Research, 2014
The objective of this study was to investigate whether a single defect in skin barrier function simulated by filaggrin silencing could induce Th2-predominant inflammation.
N.N. Dang, S.G. Pang, H.Y. Song, L.G. An, X.L. Ma   +4 more
doaj   +3 more sources

Autoantibodies recognizing citrullinated rat filaggrin in an ELISA using citrullinated and non-citrullinated recombinant proteins as antigens are highly diagnostic for rheumatoid arthritis

Clinical and Experimental Immunology, 2004
P Fardellone, A Daragon, M Jolivet
exaly   +2 more sources

Characterization of two monoclonal antibodies to human epidermal keratohyalin: reactivity with filaggrin and related proteins.

Journal of Investigative Dermatology, 1987
Two monoclonal antibodies (AKH1 and AKH2) were elicited with partially purified human filaggrin and characterized by immunohistochemistry on normal and abnormal skin biopsies, immunoblotting techniques, and antigen purification. Both antibodies react strongly with the granular cell layer consistent with the distribution of keratohyalin and show a more ...
B. Dale, A. Gown, P. Fleckman, J. R. Kimball, K. Resing   +4 more
semanticscholar   +3 more sources

Influence of Th2 Cytokines on the Cornified Envelope, Tight Junction Proteins, and ß-Defensins in Filaggrin-Deficient Skin Equivalents. [PDF]

Journal of Investigative Dermatology, 2016
Atopic dermatitis is a chronic skin condition with complex etiology. It is characterized by skin barrier defects and T helper type 2 (Th2)-polarized inflammation. Although mutations in the filaggrin gene are known to be prominent genetic risk factors for the development of atopic dermatitis, the interdependency between these and an altered cytokine ...
Stefan Hönzke, Leonie Wallmeyer, A. Ostrowski, M. Radbruch, L. Mundhenk, M. Schäfer-Korting, S. Hedtrich   +6 more
semanticscholar   +3 more sources

Investigations into the filaggrin null phenotype: showcasing the methodology for CRISPR/Cas9 editing of human keratinocytes.

Journal of Investigative Dermatology, 2023
Ever since the association between filaggrin (FLG) loss-of-function mutations and ichthyosis vulgaris and atopic dermatitis disease onset was identified, filaggrins function has been under investigation.
J. Smits, N. J. van den Brink, L. Meesters, H. Hamdaoui, H. Niehues, Patrick A. M. Jansen, I. V. van Vlijmen-Willems, D. Rodijk-Olthuis, C. Evrard, Y. Poumay, M. van Geel, W. Hendriks, J. Schalkwijk, P. Zeeuwen, E. H. van den Bogaard   +14 more
semanticscholar   +1 more source

The Discovery and Function of Filaggrin

International Journal of Molecular Sciences, 2022
Keratohyalin granules were discovered in the mid-19th century in cells that terminally differentiate to form the outer, cornified layer of the epidermis.
J. Hoober, Laura L Eggink
semanticscholar   +1 more source

Pathogenic Role of Circulating Citrullinated Antigens and Anti-Cyclic Monoclonal Citrullinated Peptide Antibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2021
We examined whether it is possible to directly detect citrullinated antigens in the serum of rheumatoid arthritis (RA) patients using a monoclonal antibody (mAb) designed to be specific for citrullinated peptides. In order to confirm the potential of the
Pureun Won, Pureun Won, Youngkyun Kim, Youngkyun Kim, Youngkyun Kim, Hyerin Jung, Hyerin Jung, Yeri Alice Rim, Yeri Alice Rim, Dong Hyun Sohn, Dong Hyun Sohn, Dong Hyun Sohn, William H. Robinson, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju   +17 more
doaj   +1 more source

Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization

Investigative Ophthalmology and Visual Science, 2023
Purpose Scleritis is a severe inflammatory ocular disorder with unknown pathogenesis. We investigated healthy sclera as well as sclera affected by noninfectious scleritis for differentially expressed proteins using a mass spectrometry approach.
D. Vergouwen, J. T. Ten Berge, Coşkun Guzel, Thierry P P van den Bosch, R. Verdijk, A. Rothova, T. Luider, M. J. Schreurs   +7 more
semanticscholar   +1 more source

Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. [PDF]

, 2012
Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), NAD(+)-dependent enzymes, link cellular energy status with responses to environmental stresses.
Benavente, Claudia A, Jacobson, Elaine L, Schnell, Stephanie A   +2 more
core   +11 more sources