Results 1 to 10 of about 589,570 (119)

Milestones in Personalized Medicine in Pemphigus and Pemphigoid

Frontiers in Immunology, 2021
Pemphigus and pemphigoid diseases are autoimmune bullous diseases characterized and caused by autoantibodies targeting adhesion molecules in the skin and/or mucous membranes.
Katja Bieber, Khalaf Kridin, Shirin Emtenani, Katharina Boch, Enno Schmidt, Enno Schmidt, Ralf J. Ludwig, Ralf J. Ludwig   +7 more
doaj   +1 more source

Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Frontiers in Immunology, 2022
Chronic blistering at the skin and/or mucous membranes, accompanied by a varying degree of inflammation, is the clinical hallmark of pemphigoid diseases that impose a major medical burden.
Saeedeh Ghorbanalipoor, Shirin Emtenani, Melissa Parker, Mayumi Kamaguchi, Colin Osterloh, Manuela Pigors, Natalie Gross, Stanislav Khil’chenko, Anika Kasprick, Sabrina Patzelt, Diana Wortmann, Ibrahim O. Ibrahim, Kentaro Izumi, Stephanie Goletz, Katharina Boch, Kathrin Kalies, Katja Bieber, Paul Smith, Enno Schmidt, Ralf J. Ludwig   +19 more
doaj   +1 more source

Topical Application of the PI3Kβ-Selective Small Molecule Inhibitor TGX-221 Is an Effective Treatment Option for Experimental Epidermolysis Bullosa Acquisita

Frontiers in Medicine, 2021
Class I phosphoinositide 3-kinases (PI3K) have been implemented in pathogenesis of experimental epidermolysis bullosa acquisita (EBA), an autoimmune skin disease caused by type VII collagen (COL7) autoantibodies.
Hannah Zillikens, Anika Kasprick, Colin Osterloh, Natalie Gross, Michael Radziewitz, Cindy Hass, Veronika Hartmann, Martina Behnen-Härer, Nancy Ernst, Katharina Boch, Gestur Vidarsson, Remco Visser, Tamás Laskay, Xinhua Yu, Frank Petersen, Ralf J. Ludwig, Katja Bieber   +16 more
doaj   +1 more source

Retrospective analysis of the long-term therapeutic effectiveness and safety profile of rituximab in the treatment of mucous membrane pemphigoid in a German university center between 2008 and 2019

Frontiers in Immunology, 2023
BackgroundThe B-cell-depleting anti-CD20 antibody rituximab (RTX) is often used as an adjuvant drug for the treatment of refractory cases of mucous membrane pemphigoid (MMP).ObjectiveThis study aims to determine the therapeutic effectiveness and the ...
Florian Bamberger, Inke R. König, Inke R. König, Damian Gola, Detlef Zillikens, Detlef Zillikens, Christian D. Sadik, Christian D. Sadik   +7 more
doaj   +1 more source

Alterations of Total Serum Immunoglobulin Concentrations in Pemphigus and Pemphigoid: Selected IgG2 Deficiency in Bullous Pemphigoid

Frontiers in Medicine, 2020
Pemphigus and pemphigoid diseases are organ-specific autoimmune diseases of the skin and/or mucous membranes, which are caused by autoantibodies targeting structural proteins of the skin.
Stanislav Khil'chenko, Stanislav Khil'chenko, Katharina Boch, Katharina Boch, Nina van Beek, Nina van Beek, Artem Vorobyev, Artem Vorobyev, Detlef Zillikens, Detlef Zillikens, Enno Schmidt, Enno Schmidt, Enno Schmidt, Ralf J. Ludwig, Ralf J. Ludwig   +14 more
doaj   +1 more source

Factors affecting upper airway control of NSAID‐exacerbated respiratory disease: A real‐world study of 167 patients

Immunity, Inflammation and Disease, 2021
Background Nonsteroidal anti‐inflammatory drug (NSAID) exacerbated respiratory disease (N‐ERD) is a triad with asthma, chronic rhinosinusitis with nasal polyps, and NSAID intolerance. Uncontrolled N‐ERD forms a major public health problem due to frequent
Annina Lyly, Anu Laulajainen‐Hongisto, Heikki Turpeinen, Seija I. Vento, Jyri Myller, Jura Numminen, Saara Sillanpää, Johanna Sahlman, Paula Kauppi, Sanna Toppila‐Salmi   +9 more
doaj   +1 more source

The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
IntroductionThe function of the second receptor for the complement cleavage product C5a, C5aR2, is poorly understood and often neglected in the immunological context.
Daniel L. Seiler, Katja H. Kähler, Marie Kleingarn, Christian D. Sadik, Christian D. Sadik, Katja Bieber, Katja Bieber, Katja Bieber, Jörg Köhl, Jörg Köhl, Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Christian M. Karsten   +13 more
doaj   +1 more source

Pathological Relevance of Anti-Hsp70 IgG Autoantibodies in Epidermolysis Bullosa Acquisita

Frontiers in Immunology, 2022
Stress-induced heat shock protein 70 (Hsp70) is a key intra- and extracellular molecular chaperone implicated in autoimmune processes. Highly immunogenic extracellular Hsp70 can activate innate and acquired (adaptive) immune responses driving the ...
Stefan Tukaj, Jagoda Mantej, Krzysztof Sitko, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz   +6 more
doaj   +1 more source

Electron microscopy of desmosomal structures in the pemphigus human skin organ culture model

Frontiers in Medicine, 2022
Pemphigus is a chronic autoimmune skin blistering disease, characterized by acantholysis and by the production of autoantibodies directed against the structural desmosomal proteins desmoglein 1 (DSG1) and/or DSG3.
Uta Katharina Radine, Valéria Bumiller-Bini Hoch, Valéria Bumiller-Bini Hoch, Angelica B. Winter Boldt, Detlef Zillikens, Detlef Zillikens, Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Christoph M. Hammers, Christoph M. Hammers, Christoph M. Hammers, Matthias Klinger, Jennifer E. Hundt, Jennifer E. Hundt   +14 more
doaj   +1 more source

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

eLife, 2016
The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain.
Alejandro Villarino, Arian Laurence, Gertraud W Robinson, Michael Bonelli, Barbara Dema, Behdad Afzali, Han-Yu Shih, Hong-Wei Sun, Stephen R Brooks, Lothar Hennighausen, Yuka Kanno, John J O'Shea   +11 more
doaj   +1 more source