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Mechanotransduction in Skin Inflammation [PDF]

Cells, 2022
In the process of mechanotransduction, the cells in the body perceive and interpret mechanical stimuli to maintain tissue homeostasis and respond to the environmental changes.
Maria S. Shutova, Wolf-Henning Boehncke
doaj   +4 more sources

Eicosanoids in skin inflammation [PDF]

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2013
Eicosanoids play an integral part in homeostatic mechanisms related to skin health and structural integrity. They also mediate inflammatory events developed in response to environmental factors, such as exposure to ultraviolet radiation, and inflammatory and allergic disorders, including psoriasis and atopic dermatitis.
Nicolaou, Anna; id_orcid, Nicolaou, Anna
openaire   +6 more sources

Post-Genomics and Skin Inflammation [PDF]

Mediators of Inflammation, 2010
Atopic dermatitis and psoriasis are two chronic skin inflammatory diseases that have so far received a greater attention within the scientific community through different post-genomic approaches; on the contrary, acne, which is undoubtedly one of the ...
Daniela Braconi, Giulia Bernardini, Annalisa Santucci   +2 more
doaj   +4 more sources

Milestones in Personalized Medicine in Pemphigus and Pemphigoid

Frontiers in Immunology, 2021
Pemphigus and pemphigoid diseases are autoimmune bullous diseases characterized and caused by autoantibodies targeting adhesion molecules in the skin and/or mucous membranes.
Katja Bieber, Khalaf Kridin, Shirin Emtenani, Katharina Boch, Enno Schmidt, Enno Schmidt, Ralf J. Ludwig, Ralf J. Ludwig   +7 more
doaj   +1 more source

Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Frontiers in Immunology, 2022
Chronic blistering at the skin and/or mucous membranes, accompanied by a varying degree of inflammation, is the clinical hallmark of pemphigoid diseases that impose a major medical burden.
Saeedeh Ghorbanalipoor, Shirin Emtenani, Melissa Parker, Mayumi Kamaguchi, Colin Osterloh, Manuela Pigors, Natalie Gross, Stanislav Khil’chenko, Anika Kasprick, Sabrina Patzelt, Diana Wortmann, Ibrahim O. Ibrahim, Kentaro Izumi, Stephanie Goletz, Katharina Boch, Kathrin Kalies, Katja Bieber, Paul Smith, Enno Schmidt, Ralf J. Ludwig   +19 more
doaj   +1 more source

The Skin and Inflamm-Aging

Biology, 2023
With its unique anatomical location facing both the external and internal environment, the skin has crucial functions, including shielding the body from damage caused by ultraviolet radiation and chemicals, preventing water loss, acting as a primary barrier against pathogens, participating in metabolic processes like vitamin D production and ...
Rashi Agrawal, Anne Hu, Wendy B. Bollag
openaire   +3 more sources

Topical Application of the PI3Kβ-Selective Small Molecule Inhibitor TGX-221 Is an Effective Treatment Option for Experimental Epidermolysis Bullosa Acquisita

Frontiers in Medicine, 2021
Class I phosphoinositide 3-kinases (PI3K) have been implemented in pathogenesis of experimental epidermolysis bullosa acquisita (EBA), an autoimmune skin disease caused by type VII collagen (COL7) autoantibodies.
Hannah Zillikens, Anika Kasprick, Colin Osterloh, Natalie Gross, Michael Radziewitz, Cindy Hass, Veronika Hartmann, Martina Behnen-Härer, Nancy Ernst, Katharina Boch, Gestur Vidarsson, Remco Visser, Tamás Laskay, Xinhua Yu, Frank Petersen, Ralf J. Ludwig, Katja Bieber   +16 more
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The role of eosinophils in skin inflammation and carcinogenesis [PDF]

, 2023
Cutaneous squamous cell carcinoma (cSCC) is one of the most common human cancers. cSCC is often associated with immune dysfunction and skin inflammation plays a prominent role in carcinogenesis.
Malaktou, Christina
core   +1 more source

Retrospective analysis of the long-term therapeutic effectiveness and safety profile of rituximab in the treatment of mucous membrane pemphigoid in a German university center between 2008 and 2019

Frontiers in Immunology, 2023
BackgroundThe B-cell-depleting anti-CD20 antibody rituximab (RTX) is often used as an adjuvant drug for the treatment of refractory cases of mucous membrane pemphigoid (MMP).ObjectiveThis study aims to determine the therapeutic effectiveness and the ...
Florian Bamberger, Inke R. König, Inke R. König, Damian Gola, Detlef Zillikens, Detlef Zillikens, Christian D. Sadik, Christian D. Sadik   +7 more
doaj   +1 more source

Alterations of Total Serum Immunoglobulin Concentrations in Pemphigus and Pemphigoid: Selected IgG2 Deficiency in Bullous Pemphigoid

Frontiers in Medicine, 2020
Pemphigus and pemphigoid diseases are organ-specific autoimmune diseases of the skin and/or mucous membranes, which are caused by autoantibodies targeting structural proteins of the skin.
Stanislav Khil'chenko, Stanislav Khil'chenko, Katharina Boch, Katharina Boch, Nina van Beek, Nina van Beek, Artem Vorobyev, Artem Vorobyev, Detlef Zillikens, Detlef Zillikens, Enno Schmidt, Enno Schmidt, Enno Schmidt, Ralf J. Ludwig, Ralf J. Ludwig   +14 more
doaj   +1 more source