Results 1 to 10 of about 876,258 (302)

Gedunin Mitigates Cutibacterium acnes-Induced Skin Inflammation by Inhibiting the NF-κB Pathway [PDF]

Pharmaceuticals
Background/Objectives: Cutibacterium acnes (C. acnes), a bacterium residing in hair follicles, triggers acne by inducing monocyte-mediated inflammatory cytokine production.
Ju Kyoung Sim, Ye Ji Heo, Jin Hak Shin, Seon Sook Kim, Su Ryeon Seo   +4 more
doaj   +2 more sources

Milestones in Personalized Medicine in Pemphigus and Pemphigoid

Frontiers in Immunology, 2021
Pemphigus and pemphigoid diseases are autoimmune bullous diseases characterized and caused by autoantibodies targeting adhesion molecules in the skin and/or mucous membranes.
Katja Bieber, Khalaf Kridin, Shirin Emtenani, Katharina Boch, Enno Schmidt, Enno Schmidt, Ralf J. Ludwig, Ralf J. Ludwig   +7 more
doaj   +1 more source

Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Frontiers in Immunology, 2022
Chronic blistering at the skin and/or mucous membranes, accompanied by a varying degree of inflammation, is the clinical hallmark of pemphigoid diseases that impose a major medical burden.
Saeedeh Ghorbanalipoor, Shirin Emtenani, Melissa Parker, Mayumi Kamaguchi, Colin Osterloh, Manuela Pigors, Natalie Gross, Stanislav Khil’chenko, Anika Kasprick, Sabrina Patzelt, Diana Wortmann, Ibrahim O. Ibrahim, Kentaro Izumi, Stephanie Goletz, Katharina Boch, Kathrin Kalies, Katja Bieber, Paul Smith, Enno Schmidt, Ralf J. Ludwig   +19 more
doaj   +1 more source

Fetal skin as a pro-inflammatory organ: Evidence from a primate model of chorioamnionitis. [PDF]

, 2017
BackgroundIntrauterine infection is a primary cause of preterm birth and fetal injury. The pro-inflammatory role of the fetal skin in the setting of intrauterine infection remains poorly characterized. Whether or not inflammation of the fetal skin occurs
Boonkasidecha, Suppawat, Jobe, Alan H, Kallapur, Suhas G, Kannan, Paranthaman Senthamarai, Kemp, Matthew W   +4 more
core   +12 more sources

Topical Application of the PI3Kβ-Selective Small Molecule Inhibitor TGX-221 Is an Effective Treatment Option for Experimental Epidermolysis Bullosa Acquisita

Frontiers in Medicine, 2021
Class I phosphoinositide 3-kinases (PI3K) have been implemented in pathogenesis of experimental epidermolysis bullosa acquisita (EBA), an autoimmune skin disease caused by type VII collagen (COL7) autoantibodies.
Hannah Zillikens, Anika Kasprick, Colin Osterloh, Natalie Gross, Michael Radziewitz, Cindy Hass, Veronika Hartmann, Martina Behnen-Härer, Nancy Ernst, Katharina Boch, Gestur Vidarsson, Remco Visser, Tamás Laskay, Xinhua Yu, Frank Petersen, Ralf J. Ludwig, Katja Bieber   +16 more
doaj   +1 more source

Full length interleukin 33 aggravates radiation-induced skin reaction [PDF]

, 2017
The interleukin (IL)-1 family member IL-33 has been described as intracellular alarmin with broad roles in wound healing, skin inflammation but also autoimmunity.
Adam, Susanne, Frey, Benjamin, Frey, Silke, Gaipl, Udo S., Gilchrist, Derek, Hahn, Madelaine, Hueber, Axel J., Krönke, Gerhard, Kurow, Olga, McInnes, Iain B., Schett, Georg, Schmitt, Verena, Schuster, Louis, Wirtz, Stefan   +13 more
core   +6 more sources

Retrospective analysis of the long-term therapeutic effectiveness and safety profile of rituximab in the treatment of mucous membrane pemphigoid in a German university center between 2008 and 2019

Frontiers in Immunology, 2023
BackgroundThe B-cell-depleting anti-CD20 antibody rituximab (RTX) is often used as an adjuvant drug for the treatment of refractory cases of mucous membrane pemphigoid (MMP).ObjectiveThis study aims to determine the therapeutic effectiveness and the ...
Florian Bamberger, Inke R. König, Inke R. König, Damian Gola, Detlef Zillikens, Detlef Zillikens, Christian D. Sadik, Christian D. Sadik   +7 more
doaj   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Alterations of Total Serum Immunoglobulin Concentrations in Pemphigus and Pemphigoid: Selected IgG2 Deficiency in Bullous Pemphigoid

Frontiers in Medicine, 2020
Pemphigus and pemphigoid diseases are organ-specific autoimmune diseases of the skin and/or mucous membranes, which are caused by autoantibodies targeting structural proteins of the skin.
Stanislav Khil'chenko, Stanislav Khil'chenko, Katharina Boch, Katharina Boch, Nina van Beek, Nina van Beek, Artem Vorobyev, Artem Vorobyev, Detlef Zillikens, Detlef Zillikens, Enno Schmidt, Enno Schmidt, Enno Schmidt, Ralf J. Ludwig, Ralf J. Ludwig   +14 more
doaj   +1 more source

Factors affecting upper airway control of NSAID‐exacerbated respiratory disease: A real‐world study of 167 patients

Immunity, Inflammation and Disease, 2021
Background Nonsteroidal anti‐inflammatory drug (NSAID) exacerbated respiratory disease (N‐ERD) is a triad with asthma, chronic rhinosinusitis with nasal polyps, and NSAID intolerance. Uncontrolled N‐ERD forms a major public health problem due to frequent
Annina Lyly, Anu Laulajainen‐Hongisto, Heikki Turpeinen, Seija I. Vento, Jyri Myller, Jura Numminen, Saara Sillanpää, Johanna Sahlman, Paula Kauppi, Sanna Toppila‐Salmi   +9 more
doaj   +1 more source