Results 21 to 30 of about 876,258 (302)
Electron microscopy of desmosomal structures in the pemphigus human skin organ culture model
Frontiers in Medicine, 2022 Pemphigus is a chronic autoimmune skin blistering disease, characterized by acantholysis and by the production of autoantibodies directed against the structural desmosomal proteins desmoglein 1 (DSG1) and/or DSG3.
Uta Katharina Radine +14 more
doaj +1 more source
Nature Communications, 2021 Increased risk of premature cardiovascular disease in systemic lupus erythematosus (SLE) is not well understood, but in animal models, the Janus kinase inhibitor tofacitinib improves related phenotypes.
Sarfaraz A. Hasni +38 more
doaj +1 more source
Skin Cell Proliferation Stimulated by Microneedles [PDF]
, 2012 A classical wound may be defined as a disruption of tissue integrity. Wounds, caused by trauma from accidents or surgery, that close via secondary intention rely on the biological phases of healing, i.e., hemostasis, inflammation, proliferation, and ...
Kloth, Luther C., Liebl, Horst
core +2 more sources
IL-4Rα Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis. [PDF]
, 2020 Dupilumab is a fully human antibody to interleukin-4 receptor α that improves the signs and symptoms of moderate to severe atopic dermatitis (AD). To determine the effects of dupilumab on Staphylococcus aureus colonization and microbial diversity on the ...
Ardeleanu, Marius +16 more
core +2 more sources
eLife, 2016 The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain.
Alejandro Villarino +11 more
doaj +1 more source
Frontiers in Immunology, 2021 Heat shock proteins (Hsp) are constitutive and stress-induced molecules which have been reported to impact innate and adaptive immune responses. Here, we evaluated the role of Hsp70 as a treatment target in the imiquimod-induced, psoriasis-like skin ...
Stefan Tukaj +8 more
doaj +1 more source
Leukotrienes orchestrating allergic skin inflammation [PDF]
Experimental Dermatology, 2013 AbstractLeukotrienes constitute a group of lipid mediators, which may be subdivided into two groups, with leukotriene B4 on the one hand and cysteinyl leukotrienes on the other. Although leukotrienes are abundantly expressed in skin affected by diverse chronic inflammatory diseases, including atopic dermatitis, psoriasis, pemphigus vulgaris and bullous
Christian D, Sadik +2 more
openaire +2 more sources
Orphanet Journal of Rare Diseases, 2021 Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic basis of susceptibility to BP, we performed the
Christian Schwarm +34 more
doaj +1 more source
Potential effects of shift work on skin autoimmune diseases
Frontiers in Immunology, 2023 Shift work is associated with systemic chronic inflammation, impaired host and tumor defense and dysregulated immune responses to harmless antigens such as allergens or auto-antigens.
Sarah Stenger +6 more
doaj +1 more source
Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]
, 2011 p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Arthur, J. Simon C. +6 more
core +3 more sources