Results 21 to 30 of about 592,890 (313)

Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus

Nature Communications, 2021
Increased risk of premature cardiovascular disease in systemic lupus erythematosus (SLE) is not well understood, but in animal models, the Janus kinase inhibitor tofacitinib improves related phenotypes.
Sarfaraz A. Hasni, Sarthak Gupta, Michael Davis, Elaine Poncio, Yenealem Temesgen-Oyelakin, Philip M. Carlucci, Xinghao Wang, Mohammad Naqi, Martin P. Playford, Rishi R. Goel, Xiaobai Li, Ann J. Biehl, Isabel Ochoa-Navas, Zerai Manna, Yinghui Shi, Donald Thomas, Jinguo Chen, Angélique Biancotto, Richard Apps, Foo Cheung, Yuri Kotliarov, Ashley L. Babyak, Huizhi Zhou, Rongye Shi, Katie Stagliano, Wanxia Li Tsai, Laura Vian, Nathalia Gazaniga, Valentina Giudice, Shajia Lu, Stephen R. Brooks, Meggan MacKay, Peter Gregersen, Nehal N. Mehta, Alan T. Remaley, Betty Diamond, John J. O’ Shea, Massimo Gadina, Mariana J. Kaplan   +38 more
doaj   +1 more source

Therapeutic Implications of Targeting Heat Shock Protein 70 by Immunization or Antibodies in Experimental Skin Inflammation

Frontiers in Immunology, 2021
Heat shock proteins (Hsp) are constitutive and stress-induced molecules which have been reported to impact innate and adaptive immune responses. Here, we evaluated the role of Hsp70 as a treatment target in the imiquimod-induced, psoriasis-like skin ...
Stefan Tukaj, Jagoda Mantej, Michał Sobala, Katarzyna Potrykus, Zbigniew Tukaj, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz   +8 more
doaj   +1 more source

A new method for extracting skin microbes allows metagenomic analysis of whole-deep skin [PDF]

, 2013
In the last decade, an extensive effort has been made to characterize the human microbiota, due to its clinical and economic interests. However, a metagenomic approach to the skin microbiota is hampered by the high proportion of host DNA that is ...
Francesc Calafell, Koldo Garcia-Etxebarria, Garcia-Etxebarria, Koldo, Marc Garcia-Garcerà (3214074), Mireia Coscollà (149823), Calafell, Francesc, Amparo Latorre (88013), Calafell, Francesca, Garcia-Garcerà, Marc, Koldo Garcia-Etxebarria (461325), Coscollà, Mireia, Marc Garcia-Garcerà, Amparo Latorre, Francesc Calafell (148375), Latorre, Amparo, Mireia Coscollà   +15 more
core   +1 more source

Potential effects of shift work on skin autoimmune diseases

Frontiers in Immunology, 2023
Shift work is associated with systemic chronic inflammation, impaired host and tumor defense and dysregulated immune responses to harmless antigens such as allergens or auto-antigens.
Sarah Stenger, Hanna Grasshoff, Jennifer Elisabeth Hundt, Jennifer Elisabeth Hundt, Tanja Lange, Tanja Lange, Tanja Lange   +6 more
doaj   +1 more source

ON THE TREATMENT OF INFLAMMATION OF THE SKIN. [PDF]

The Lancet
n ...
Snow, John, Snow, John
openaire   +2 more sources

Current Clinical Trials in Pemphigus and Pemphigoid

Frontiers in Immunology, 2019
Autoimmune bullous dermatoses (AIBDs) are a group of rare chronic inflammatory skin diseases, which clinically manifest as blisters and erosions of the skin and/or mucosa.
Kentaro Izumi, Kentaro Izumi, Katja Bieber, Ralf J. Ludwig   +3 more
doaj   +1 more source

Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans

Orphanet Journal of Rare Diseases, 2021
Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic basis of susceptibility to BP, we performed the
Christian Schwarm, Damian Gola, Maike M. Holtsche, Anabelle Dieterich, Anita Bhandari, Miriam Freitag, Peter Nürnberg, Mohammad Toliat, Wolfgang Lieb, Michael Wittig, André Franke, Margitta Worm, Michael Sticherling, Jan Ehrchen, Claudia Günther, Regine Gläser, Wiebke K. Peitsch, Miklós Sárdy, Rüdiger Eming, Michael Hertl, Sandrine Benoit, Matthias Goebeler, Claudia Pföhler, Manfred Kunz, Alexander Kreuter, Nina van Beek, Jeanette Erdmann, Hauke Busch, Detlef Zillikens, Christian D. Sadik, Misa Hirose, Inke R. König, Enno Schmidt, Saleh M. Ibrahim, German AIBD Study Group   +34 more
doaj   +1 more source

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis [PDF]

, 2014
Background: Atopic dermatitis (AD; eczema) is characterized by a widespread abnormality in cutaneous barrier function and propensity to inflammation. Filaggrin is a multifunctional protein and plays a key role in skin barrier formation.
Sherstnev, Alexander, O'Regan, Grainne M., Schurch, Nicholas J., Barton, Geoffrey J., Sandilands, Aileen, Irvine, Alan D., Brown, Sara J., Kroboth, Karin, Cole, Christian, Cole, Christian; id_orcid, Watson, Rosemarie M., Barton, Geoffrey J.; id_orcid, McLean, W. H. Irwin, Irwin McLean, W.H.   +13 more
core   +1 more source

Age-Related Alterations in Macrophage Distribution and Function Are Associated With Delayed Cutaneous Wound Healing

Frontiers in Immunology, 2022
Ageing-related delays and dysregulated inflammation in wound healing are well-documented in both human and animal models. However, cellular and molecular changes underlying this impairment in healing progression are not fully understood.
Christabel Thembela Dube, Christabel Thembela Dube, Yasmin Hui Binn Ong, Kelly Wemyss, Kelly Wemyss, Siddharth Krishnan, Siddharth Krishnan, Tiak Ju Tan, Baptiste Janela, Baptiste Janela, John R. Grainger, John R. Grainger, Matthew Ronshaugen, Kimberly A. Mace, Chin Yan Lim, Chin Yan Lim   +15 more
doaj   +1 more source

The Burden of Genital Warts in Finland: Cross-Sectional Analysis of the Prevalence and Direct Medical Costs in 2018

Vaccines, 2023
Genital warts (GWs) caused by the human papilloma virus (HPV) are a significant health problem due to high prevalence and rate of recurrence. Bivalent vaccine has been used since the start of the national vaccination program in 2013, making it feasible ...
Annette Gylling, Kristiina Uusi-Rauva, Iiro Toppila, Eija Hiltunen-Back   +3 more
doaj   +1 more source