Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice [PDF]
, 2013 The inflammatory response is normally limited by mechanisms regulating its resolution. In the absence of resolution, inflammatory pathologies can emerge, resulting in substantial morbidity and mortality.
Baldwin, H.M. +9 more
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Chronic Inflammation in Skin Malignancies
Journal of Molecular Signaling, 2016 Chronic inflammation is linked to the development and progression of multiple cancers, including those of the lung, stomach, liver, colon, breast and skin. Inflammation not only drives the oncogenic transformation of epithelial cells under the stress of chronic infection and autoimmune diseases, but also promotes the growth, progression and metastatic ...
Tang, Lihua, Wang, Kepeng
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Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [PDF]
, 2020 Netherton syndrome (NS) is a monogenic skin disease resulting from loss of function of lymphoepithelial Kazal-type-related protease inhibitor (LEKTI-1).
Butcher, Anna M +12 more
core
Epigenomic Views of Innate Lymphoid Cells
Frontiers in Immunology, 2017 The discovery of innate lymphoid cells (ILCs) with selective production of cytokines typically attributed to subsets of T helper cells forces immunologists to reassess the mechanisms by which selective effector functions arise.
Giuseppe Sciumè +3 more
doaj +1 more source
Tetracycline Actions Relevant to Rosacea Treatment [PDF]
, 2009 Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of
Korting, Hans Christian, Schöllmann, C.
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Biology, 2023 Background: Cannabinoids are mainly used for recreational purposes, but also made their way into oncology, since these substances can be taken to increase appetite in tumour cachexia.
Georg Richtig +8 more
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Chronic Skin-Specific Inflammation Promotes Vascular Inflammation and Thrombosis [PDF]
Journal of Investigative Dermatology, 2012 Patients with psoriasis have systemic and vascular inflammation and are at increased risk for myocardial infarction, stroke, and cardiovascular death. However, the underlying mechanism(s) mediating the link between psoriasis and vascular disease is incompletely defined.
Wang, Yunmei +9 more
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Morbidity and Causes of Death in Patients with Cutaneous T-cell Lymphoma in Finland
Acta Dermato-Venereologica, 2017 Cutaneous T-cell lymphomas (CTCL), especially mycosis fungoides, can be considered as a state of longstanding low-grade systemic inflammation.
Liisa Väkevä +3 more
doaj +1 more source
Neutrophils Affect IL-33 Processing in Response to the Respiratory Allergen Alternaria alternata
Frontiers in Immunology, 2021 Future precision medicine requires further clarifying the mechanisms of inflammation in the severe endotypes of chronic airway diseases such as asthma and chronic rhinosinusitis (CRS).
Sharon Van Nevel +10 more
doaj +1 more source
Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy. [PDF]
, 2016 Rosacea is a chronic inflammatory disease with transient and non-transient redness as key characteristics. Brimonidine is a selective α2-adrenergic receptor (AR) agonist approved for persistent facial erythema of rosacea based on significant efficacy and
Detmar, Michael +6 more
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