Results 31 to 40 of about 592,890 (313)

Molecular Mechanisms of Neurogenic Inflammation of the Skin

International Journal of Molecular Sciences, 2023
The skin, including the hypodermis, is the largest body organ and is in constant contact with the environment. Neurogenic inflammation is the result of the activity of nerve endings and mediators (neuropeptides secreted by nerve endings in the development of the inflammatory reaction in the skin), as well as interactions with other cells such as ...
Luiza Marek-Jozefowicz, Bogusław Nedoszytko, Małgorzata Grochocka, Michał A. Żmijewski, Rafał Czajkowski, Wiesław J. Cubała, Andrzej T. Slominski   +6 more
openaire   +2 more sources

Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Nature Communications, 2019
Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions ...
Artem Vorobyev, Yask Gupta, Tanya Sezin, Hiroshi Koga, Yannic C. Bartsch, Meriem Belheouane, Sven Künzel, Christian Sina, Paul Schilf, Heiko Körber-Ahrens, Foteini Beltsiou, Anna Lara Ernst, Stanislav Khil’chenko, Hassanin Al-Aasam, Rudolf A. Manz, Sandra Diehl, Moritz Steinhaus, Joanna Jascholt, Phillip Kouki, Wolf-Henning Boehncke, Tanya N. Mayadas, Detlef Zillikens, Christian D. Sadik, Hiroshi Nishi, Marc Ehlers, Steffen Möller, Katja Bieber, John F. Baines, Saleh M. Ibrahim, Ralf J. Ludwig   +29 more
doaj   +1 more source

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1 [PDF]

, 2010
If insufficiently treated, Lyme borreliosis can evolve into an inflammatory disorder affecting skin, joints, and the CNS. Early innate immunity may determine host responses targeting infection. Thus, we sought to characterize the immediate cytokine storm
Nicole Darsow, Kind, Peter, Rudloff, Ina, Klaus-Peter Hunfeld, Katharina Horn, Itamar Goren, Urs Christen, Kraiczy Peter, Horn Katharina, Pfeilschifter, Josef (Prof. Dr.), Mühl Heiko, Koehl Ulrike, Peter Kind, Goren Itamar, Pfeilschifter, Josef, Peter Kraiczy, Rudloff Ina, Goren, Itamar, Mühl, Heiko, Darsow, Nicole, Christen Urs, Kraiczy, Peter, Christen, Urs, Holdener, Martin, Horn, Katharina, Hunfeld, Klaus-Peter, Ulrike Koehl, Hunfeld Klaus-Peter, Heiko Mühl, Ina Rudloff, Malte Bachmann, Martin Holdener, Holdener Martin, Koehl, Ulricke, Bachmann Malte, Darsow Nicole, Kind Peter, Köhl, Ulrike, Josef Pfeilschifter, Bachmann, Malte, Pfeilschifter Josef   +40 more
core   +1 more source

Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation [PDF]

, 2010
The role of lymphangiogenesis in inflammation has remained unclear. To investigate the role of lymphatic versus blood vasculature in chronic skin inflammation, we inhibited vascular endothelial growth factor (VEGF) receptor (VEGFR) signaling by function ...
Steven T. Proulx, Stefan Ullmann, Kari Alitalo, Alitalo, Kari, Detmar, Michael, Bronislaw Pytowski, Proulx, Steven T., Ullmann, Stefan, Reto Huggenberger, Pytowski, Bronislaw, Proulx, Steven T, Huggenberger, Reto, Michael Detmar   +12 more
core   +1 more source

Epigenomic Views of Innate Lymphoid Cells

Frontiers in Immunology, 2017
The discovery of innate lymphoid cells (ILCs) with selective production of cytokines typically attributed to subsets of T helper cells forces immunologists to reassess the mechanisms by which selective effector functions arise.
Giuseppe Sciumè, Han-Yu Shih, Yohei Mikami, John J. O’Shea   +3 more
doaj   +1 more source

Ultraviolet Induced Skin Inflammation

International Journal of Dermatology and Venerology, 2021
. Ultraviolet (UV) induced skin inflammation (UISI) is associated with many skin disorders. However, the mechanism by which UV causes skin inflammation remains unclear.
Hai-Chao Zhao, Ta Xiao, Yu-Jie Chen
doaj   +1 more source

The Skin Epilipidome in Stress, Aging, and Inflammation [PDF]

Frontiers in Endocrinology, 2021
Lipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface lipids, together regulating permeability, physical properties, acidification and the antimicrobial ...
Florian Gruber, Florian Gruber, Florian Gruber, Martina Marchetti-Deschmann, Martina Marchetti-Deschmann, Christopher Kremslehner, Christopher Kremslehner, Christopher Kremslehner, Markus Schosserer, Markus Schosserer, Markus Schosserer   +10 more
openaire   +3 more sources

Chronic Inflammation in Skin Malignancies

Journal of Molecular Signaling, 2016
Chronic inflammation is linked to the development and progression of multiple cancers, including those of the lung, stomach, liver, colon, breast and skin. Inflammation not only drives the oncogenic transformation of epithelial cells under the stress of chronic infection and autoimmune diseases, but also promotes the growth, progression and metastatic ...
Tang, Lihua, Wang, Kepeng
openaire   +4 more sources

Effects of resveratrol in ınflammatory arthritis [PDF]

, 2007
Inflammation, Vol. 30, Nos. 1Y2, April 2007 ( 2006)Summary: Nuclear factor kappa B (NF-kB), is a pivotal transcription factor involved in the activation of the TNF-a and IL-1b genes.
Baysal, Özlem, Esenkaya, İrfan, Mızrak, Bülent, Elmalı, Nurzat, Harma, Ahmet   +4 more
core   +1 more source

Cannabinoids Reduce Melanoma Cell Viability and Do Not Interfere with Commonly Used Targeted Therapy in Metastatic Melanoma In Vivo and In Vitro

Biology, 2023
Background: Cannabinoids are mainly used for recreational purposes, but also made their way into oncology, since these substances can be taken to increase appetite in tumour cachexia.
Georg Richtig, Melanie Kienzl, Sonja Rittchen, David Roula, Jürgen Eberle, Zina Sarif, Martin Pichler, Gerald Hoefler, Akos Heinemann   +8 more
doaj   +1 more source