Results 61 to 70 of about 876,258 (302)

The Role of Invasive Procedures in the Treatment of Complicated Gastrointestinal Graft‐Versus‐Host Disease in Pediatric Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti, Giorgio Persano, Chiara Grimaldi, Pier Luigi Di Paolo, Carmen Malaspina, Francesco Quagliarella, Valerio Balassone, Anna Chiara Iolanda Contini, Gian Luigi Natali, Rita Alaggio, Ivan Pietro Aloi, Tamara Caldaro, Alessandro Crocoli   +12 more
wiley   +1 more source

Comorbidities of chronic rhinosinusitis in children and adults

Clinical and Translational Allergy
Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nose and paranasal sinuses lasting ≥12 weeks. CRS may exist with (CRSwNP) or without (CRSsNP) nasal polyps.
Aada Murtomäki, Alma Helevä, Paulus Torkki, Jari Haukka, Anna Julkunen‐Iivari, Riikka Lemmetyinen, Mika Mäkelä, Aarno Dietz, Mikko Nuutinen, Sanna Toppila‐Salmi   +9 more
doaj   +1 more source

In Vitro and Ex Vivo Models for Screening Topical Anti-Inflammatory Drugs

Scientia Pharmaceutica, 2023
Skin inflammation occurs as an immune response to various stimuli such as ultraviolet light, irritants, or any type of skin barrier injury. Finding safe and effective drugs to combat skin inflammation remains a research challenge.
Juan Luis Pérez-Salas, Martha Rocío Moreno-Jiménez, Nuria Elizabeth Rocha-Guzmán, Rubén Francisco González-Laredo, Luis Medina-Torres, José Alberto Gallegos-Infante   +5 more
doaj   +1 more source

Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy [PDF]

, 2017
BACKGROUND. Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments.
Ahu Turkoz, Andras Schaffer, Arturo P. Saavedra, Cipolat, Fenske, Hengameh Mirzaalian, Jean-Pierre Eliane, Lynn A. Cornelius, Mary Tabacchi, Michael Wallendorf, Raphael Kopan, Salasche, Sara Moradi Tuchayi, Seckin, Shadmehr Demehri, Sindhu Manivasagam, Stockfleth, Trevor J. Cunningham, Warino   +18 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Bach2-deficient mice are prone to autoimmune pancreatitis but protected from high-fat diet-induced fatty liver disease

Frontiers in Immunology
BackgroundAutoimmune pancreatitis (AIP) is a multifactorial disease caused by both genetic and environmental factors. Previous studies have implicated Bach2, a key regulator of adaptive immunity, in the pathogenesis of this disease.
Luise Ehlers, Anika Kasprick, Ottavia Agrifoglio, Natalie Gross, Nancy Ernst, Alanis Barbosa Gulde, Colin Osterloh, Noa Linn Brauckmann, Nicole Y. Fischer, Wendy Bergmann-Ewert, Ralf J. Ludwig, Katja Bieber, Robert Jaster   +12 more
doaj   +1 more source

TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain [PDF]

, 2016
Background: The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system.
A Boivin, A Constant, A Walter, AD Bachstetter, Alison McColl, B Winner, BT Fife, C Callewaere, C D'Mello, C Gemma, CA Thomson, Carolyn A. Thomson, CP Marques, CS McKimmie, CT Ekdahl, D Michlmayr, D Michlmayr, EE Ubogu, G Banisadr, G Banisadr, Gerard J. Graham, JH Dufour, JL Teeling, Jonathan Cavanagh, JS Cameron, JS Snyder, JT Rogers, L Azzi, L Cartier, L Fits van der, Louis Nerurkar, M Baggiolini, M Udina, ML Monje, MM Lee, N Andrews, Q Liu, R Dantzer, R Deacon, R Krishnan, R Rola, RM Deacon, RM Ransohoff, S Baraldi, S Goethals, S Potvin, S Tyring, SM O'Brien, U Patel, U Puntener, W Huang da, W Huang da, W Rostene, WJ Karpus   +53 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Could Inflammaging and Its Sequelae Be Prevented or Mitigated? [PDF]

, 2019
Aged humans display a chronic and low-grade inflammation, termed "inflammaging", which has been potentially linked to the subsequent development of some aging-associated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular ...
Elias, Peter M, Man, Mao-Qiang
core  

Type 2 Innate Lymphoid Cells in Allergic Disease. [PDF]

, 2013
Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin.
Doherty, Taylor A, Lund, Sean, Walford, Hannah H   +2 more
core   +2 more sources