Results 61 to 70 of about 592,890 (313)

Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans [PDF]

, 2007
The aim of this study was to investigate local opioid effects in the inflamed skin of healthy human volunteers. To induce inflammation, the circular tip of a 10-mm-diameter probe was heated to 48°C and applied for 120 seconds to a site on each forearm of
Hammond, G.R., Drummond, P.D., Robertson, L.   +2 more
core   +1 more source

Bach2-deficient mice are prone to autoimmune pancreatitis but protected from high-fat diet-induced fatty liver disease

Frontiers in Immunology
BackgroundAutoimmune pancreatitis (AIP) is a multifactorial disease caused by both genetic and environmental factors. Previous studies have implicated Bach2, a key regulator of adaptive immunity, in the pathogenesis of this disease.
Luise Ehlers, Anika Kasprick, Ottavia Agrifoglio, Natalie Gross, Nancy Ernst, Alanis Barbosa Gulde, Colin Osterloh, Noa Linn Brauckmann, Nicole Y. Fischer, Wendy Bergmann-Ewert, Ralf J. Ludwig, Katja Bieber, Robert Jaster   +12 more
doaj   +1 more source

Clinical application of serum biomarkers for detecting and monitoring of chronic plaque psoriasis

Frontiers in Molecular Biosciences, 2023
Psoriasis, a chronic, multisystemic inflammatory disease affecting millions of people globally, manifests as erythematous, thick, scaly plaques on the skin. Clinical evaluation remains to be the benchmark for diagnosis and monitoring of this debilitating
Criselda Jean G. Cruz, Criselda Jean G. Cruz, Chao-Chun Yang, Chao-Chun Yang   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation [PDF]

, 2018
International audienceAccumulation of large-scale mitochondrial DNA (mtDNA) deletions and chronic, subclinical inflammation are concomitant during skin aging, thus raising the question of a causal link.
Baris, Olivier, Weiland, Daniela, Neuhaus, Johannes, F G, Tobin, Desmond, J., Niessen, Carien, M, Holzer, Tatjana, Brachvogel, Bent, Hornig-Do, Hue-Tran, Neuhaus, Johannes F.G., Wiesner, Rudolf, J   +9 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation [PDF]

, 2018
Summary: Psoriasis is a chronic relapsing, remitting interleukin (IL)-23/IL-17-driven skin disease mediated by the interplay of T cells and polymorphonuclear granulocytes. Although preclinical studies have provided insights into the mechanisms of disease
Tom Hartwig, Lukas Flatz, Burkhard Becher, Hartwig, Tom, Curdin Conrad, Yawalkar, Nikhil, Schlapbach, Christoph, Schreiner, B., Alexander Navarini, Pascale Zwicky, Christoph Schlapbach, Conrad, Curdin, Reinhard Dummer, Cheng, Phil; https://orcid.org/, Yawalkar, N., Navarini, A., Schreiner, Bettina, Cheng, P., Becher, Burkhard, Dummer, R., Schlapbach, C., Becher, B., Phil Cheng, Dummer, Reinhard, Zwicky, P., Nikhil Yawalkar, Hartwig, T., Bettina Schreiner, Flatz, Lukas, Flatz, L., Cheng, Phil, Becher, Burkhard; https://orcid.org/, Conrad, C., Navarini, Alexander, Zwicky, Pascale   +34 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease [PDF]

, 2017
Sebastian Majewski,1,2 Anna Pietrzak,3 Damian Tworek,4 Karolina Szewczyk,5 Anna Kumor-Kisielewska,1 Zofia Kurmanowska,5 Paweł Górski,1,2 Anna Zalewska-Janowska,3,* Wojciech Jerzy Piotrowski1,2,* 1Department of Pneumology and Allergy, Medical ...
Pietrzak A, Majewski S, Kurmanowska Z, Kumor-Kisielewska A, Szewczyk K, Górski P, Tworek D, Zalewska-Janowska A, Piotrowski WJ   +8 more
core  

T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva (TM)): Mechanisms of action [PDF]

, 2004
Psoriasis is a chronic, incurable, auto-immune disorder with cutaneous manifestations. New evidence on the central role of the immune system in the pathogenesis of psoriasis increasingly provides insight into pathogenic steps that can be modulated to ...
Caro, I., Jullien, D., Langley, RGB, Dedrick, R., Prinz, Jörg Christoph, Joshi, A., Natta, P., Dummer, W.   +7 more
core   +1 more source