Results 51 to 60 of about 6,491,911 (254)

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. [PDF]

, 2015
Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth.
Adams, Alam, Alvarado, Arin, Baris, Bianchi, Bligh, Bunick, Bär, Böttinger, Candi, Candi, Capetanaki, Chan, Chernoivanenko, Christina B. Brazel, Chung, Coulombe, Coulombe, Crowe, Dennis R. Roop, Duan, Egberts, Ellis, Epand, Fessing, Fontanesi, Fuchs, Fuchs, Gendronneau, Geng, Habtezion, Haines, Hamanaka, Hans Binder, Hardman, Helenius, Henry Löffler-Wirth, Herrmann, Hesse, Hoefs, Homberg, Homberg, Hornig-Do, Hoste, Hue-Tran Hornig-Do, Huebner, Jamal-Eddine Bouameur, Janina Bär, Jaquemar, Jarnik, Jayaprakash, Kalinin, Kato, Kawasaki, Kerns, Kim, Kim, Kloepper, Koch, Kröger, Kröger, Kuramoto, Kypriotou, Laatsch, Lane, Langbein, Lessard, Lim, Loschke, Macdiarmid, Magin, Matsui, Matsuki, McAleer, Mor-Vaknin, Nakamichi, Nestle, Nicole Schwarz, Nishizawa, Norlén, Oji, Owens, Palmer, Panjwani, Paradies, Peter Seibel, Preethi Vijayaraj, Quigley, Reichelt, Reichelt, Reichelt, Rice, Rice, Rice, Robert H. Rice, Roop, Rorke, Roth, Roth, Rowland, Rudolf E. Leube, Rudolf J. Wiesner, Sabharwal, Sakaguchi, Samuelov, Samuelov, Sandilands, Sandra Heller, Schmuth, Schweizer, Schäfer, Schäfer, Segre, Segre, Seltmann, Seltmann, Seltmann, Sevilla, Signorelli, Simpson, Singla, Smith, Susanne Brodesser, Szeverenyi, Sören Thiering, Takahashi, Tamai, Tao, Tasseva, Tatsuta, Thomas M. Magin, Vijayaraj, Vijayaraj, Vinod Kumar, Wallace, Watt, Yao, Yu, Zeeuwen, Özbalci   +140 more
core   +1 more source

Role of genetic aspect in pathogenesis of atopic dermatitis [PDF]

, 2013
The pathogenesis of atopic dermatitis (AD) is a very complicated process that involves an intricate array of molecules. Nowadays it is generally accepted that cytokines play an important role in the progression of the clinical presentation of atopic ...
Wesserling Martyna
core   +2 more sources

Atopic Dermatitis Host and Environment Model: Revisiting Therapeutic Options [PDF]

, 2020
Atopic Dermatitis affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of
Abreu, C, Lopes, A, Lopes, C, Sokolova, A   +3 more
core   +1 more source

Roles and regulation of membrane-associated serine proteases [PDF]

, 2007
Pericellular proteolytic activity affects many aspects of cellular behaviour, via mechanisms involving processing of the extracellular matrix, growth factors and receptors.
Bass, Rosemary, Ellis, V, Gray, Kelly, Owen, K, Qiu, Deyi   +4 more
core   +1 more source

Genomic, Epigenomic, Transcriptomic, Proteomic and Metabolomic Approaches in Atopic Dermatitis

Current Issues in Molecular Biology, 2023
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a high prevalence in the developed countries. It is associated with atopic and non-atopic diseases, and its close correlation with atopic comorbidities has been genetically demonstrated ...
Dalia Bratu, Daniel Boda, Constantin Caruntu   +2 more
doaj   +1 more source

GRANZYME B CONTRIBUTES TO BARRIER DYSFUNCTION IN OXAZOLONE-INDUCED SKIN INFLAMMATION THROUGH E-CADHERIN AND FILAGGRIN CLEAVAGE.

Journal of Investigative Dermatology, 2020
Atopic dermatitis (AD) is the most common inflammatory skin condition. Skin barrier dysfunction is of major importance in AD as it facilitates allergen sensitization and systemic allergic responses.
Christopher T. Turner, Matthew R. Zeglinski, K. Richardson, Stephanie Santacruz, S. Hiroyasu, Christine Wang, Hongyan Zhao, Yue-ming Shen, R. Sehmi, H. Lima, G. Gauvreau, D. Granville   +11 more
semanticscholar   +1 more source

Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus

Journal of Allergy and Clinical Immunology, 2010
Colonization of the skin by Staphylococcus aureus in individuals with atopic dermatitis exacerbates inflammation. Atopic dermatitis is associated with loss-of-function mutations in the filaggrin (FLG) gene, accompanied by reduced levels of filaggrin breakdown products on the skin.To assess the affect of growth in the presence of the filaggrin breakdown
Miajlovic, Helen, Fallon, Padraic G., Irvine, Alan D., Foster, Timothy J.   +3 more
openaire   +4 more sources

Crossing Barriers; Restoring Barriers? Filaggrin Protein Replacement Takes a Bow [PDF]

Journal of Investigative Dermatology, 2014
In this issue of the Journal, Stout and colleagues report a novel and creative approach to replacement of genetically determined absence or deficiency of epidermal proteins. While these early data are certainly interesting, further validation work is required to determine the utility of this approach in genodermatoses.
openaire   +3 more sources

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis [PDF]

, 2016
Background Filaggrin, which is encoded by the filaggrin gene (FLG), is an important component of the skin's barrier to the external environment, and genetic defects in FLG strongly associate with atopic dermatitis (AD).
Aishath S. Naeem, Aneskievich, Asselineau, Balgi, Benjamin Way, Bonnart, Brasch, Brown, Brown, Buhling, Burgess, Byrne, Callard, Chawla, Christian Cole, Cole, Cork, Cristina Tommasi, D'Angelo, de Veer, Denecker, Diepgen, Dunham, Egberts, Ellinghaus, Faiz, Fallon, Flentke, Grahovac, Gruber, Guttman-Yassky, Hirota, Howell, Jakasa, Janes, John I. Harper, Kasraie, Kawada, Kawada, Kezic, Kim, Kuo, Lambert, Le, Li, Li, List, Matsui, Miriam Moffatt, Modena, O'Regan, O'Shaughnessy, O'Shaughnessy, Palmer, Pellerin, Rendl, Rosenthal, Ruzicka, Ryan F.L. O'Shaughnessy, Saffron A.G. Willis Owen, Sandilands, Sandilands, Sara J. Brown, Seguchi, Sevilla, Smith, Soumelis, Stuart J. Brown, Sully, Sun, Thomas Reinheckel, Thrash, Vavrova, Wei-Li Di, Weidinger, William O. Cookson, Yanan Zhu   +76 more
core   +7 more sources

Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin [PDF]

, 2004
Antibodies directed to the Sa antigen are highly specific for rheumatoid arthritis ( RA) and can be detected in approximately 40% of RA sera. The antigen, a doublet of protein bands of about 50 kDa, is present in placenta and in RA synovial tissue ...
Vossenaar, E.R., Despres, N., Lapointe, E., Heijden, A.G. van der, Lora, M., Senshu, T., Venrooij, W.J.W. van, Menard, H.A.   +7 more
core   +1 more source