Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptides in rheumatoid arthritis [PDF]
, 2009 Introduction: Evidence suggests that citrullinated fibrin(ogen) may be a potential in vivo target of anticitrullinated protein/peptide antibodies (ACPA) in rheumatoid arthritis (RA).
Alejandro Balsa +11 more
core +2 more sources
Evolutionary diversification of epidermal barrier genes in amphibians
Scientific Reports, 2022 The epidermal differentiation complex (EDC) is a cluster of genes encoding components of the skin barrier in terrestrial vertebrates. EDC genes can be categorized as S100 fused-type protein (SFTP) genes such as filaggrin, which contain two coding exons ...
Attila Placido Sachslehner +1 more
doaj +1 more source
Epidermal Immunity and Function: Origin in Neonatal Skin
Frontiers in Molecular Biosciences, 2022 The fascinating story of epidermal immunity begins in utero where the epidermal barrier derives from the ectoderm and evolves through carefully orchestrated biological processes, including periderm formation, keratinocyte differentiation, proliferation ...
Marty O. Visscher +2 more
doaj +1 more source
Recent positive selection in genes of the mammalian epidermal differentiation complex locus [PDF]
, 2017 The epidermal differentiation complex (EDC) is the most rapidly evolving locus in the human genome compared to that of the chimpanzee. Yet the EDC genes that are undergoing positive selection across mammals and in humans are not known.
Goodwin, Zane A +1 more
core +2 more sources
Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown [PDF]
Journal of Dermatological Science, 2017 Deimination (also known as citrullination), the conversion of arginine in a protein to citrulline, is catalyzed by a family of enzymes called peptidylarginine deiminases (PADs). Three PADs are expressed in the epidermis, one of their targets being filaggrin.
Cau, Laura +7 more
openaire +4 more sources
Journal of Nanobiotechnology, 2023 Atopic dermatitis (AD) is a common skin disease involving important immune mechanisms. There is an unmet need for a treatment for this condition. Herein, we focused on elucidating the role of Bi2-xMnxO3 nanospheres (BM) in alleviating skin inflammation ...
Mengjie Li +10 more
doaj +1 more source
Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity:Implications for atopic dermatitis [PDF]
, 2018 Background: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products [natural moisturizing factors (NMFs ...
Barrett +49 more
core +3 more sources
Scientific Reports, 2020 Active ingredients derived from natural sources are widely utilized in many industries. Cosmetic active ingredients are largely derived from various plants.
Kyung-Ha Lee, Jeong Pyo Lee, Wanil Kim
doaj +1 more source
Mesenchymal stem cells express epidermal markers in an in vitro reconstructed human skin model
Frontiers in Cell and Developmental Biology, 2023 Introduction: In skin traumas, such as burns, epidermal homeostasis is affected, often requiring clinical approaches. Different therapeutic strategies can be used including transplantation, besides the use of synthetic or natural materials with ...
Jeniffer Farias Dos Santos +6 more
doaj +1 more source
The epidthelial sodium channel ENaC and its regulators in the epidermal permeability barrier function [PDF]
, 2010 The highly amiloride-sensitive epithelial sodium channel ENaC is well known to be involved in controlling whole body sodium homeostasis and lung liquid clearance. ENaC expression has also been detected in the skin of amphibians and mammals.
Charles, R-P. +2 more
core +1 more source