Auswirkungen der Hautbarrierestörung in Filaggrin- und Hornerin(FlgHrnr)-defizienten Mäusen auf den atopischen Marsch [PDF]
, 2022 Loss-of-function mutations in skin barrier proteins, such as filaggrin (Flg) and hornerin (Hrnr), are known major risks for atopic dermatitis (AD) and the further development of asthma, a process known as atopic march.
Reier, Konstantin
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Central Asian Journal of Medical SciencesObjective: The complex interplay between genetic and external factors contributes to the multifactorial nature of atopic dermatitis (AD). The study aimed to use next-generation sequencing (NGS) to identify and describe genetic alterations and ...
Lkhamdari Batbileg +5 more
doaj +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
The Genetics of Atopic Eczema in the Bangladeshi population of East London [PDF]
, 2009 PhDAtopic Eczema (AE) is a common, complex, genetic skin disease. It usually begins in infancy and can affect any part of the body but often occurs in the flexures of the elbows and knees. The cohort used in this study is of Bangladeshi origin and all
Sinclair, Claire
core
Loss of Normal Profilaggrin and Filaggrin in Flaky Tail (ft/ft) Mice: an Animal Model for the Filaggrin-Deficient Skin Disease Ichthyosis Vulgaris [PDF]
, 2000 Flaky tail (gene symbol ft) is an autosomal recessive mutation in mice that results in a dry, flaky skin, and annular tail and paw constrictions in the neonatal period.
Presland, Richard B. +11 more
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Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food
Allergy, EarlyView.ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy +7 more
wiley +1 more source
Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen [PDF]
Journal of Allergy and Clinical Immunology, 2009 Filaggrin is important for skin barrier function and is mutated in 15% to 20% of patients with atopic dermatitis.To examine whether filaggrin deficiency predisposes to skin inflammation and epicutaneous sensitization with protein antigen.Skin histology in filaggrin-deficient flaky tail (ft)/ft mice and wild-type controls was assessed by Hematoxylin and
Michiko K, Oyoshi +2 more
openaire +2 more sources
Knockdown of Filaggrin in a Three-Dimensional Reconstructed Human Epidermis Impairs Keratinocyte Differentiation [PDF]
, 2014 Atopic dermatitis is a chronic inflammatory skin disorder characterized by defects in the epidermal barrier and keratinocyte differentiation. The expression of filaggrin, a protein thought to have a major role in the function of the epidermis, is ...
Schmitt, Anne-Marie +13 more
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Structural and functional characterisation of filaggrin-hornerin (FlgHrnr-/- ) double-deficient mice [PDF]
, 2020 Filaggrin (Flg) and hornerin (Hrnr) share similar structural and functional features. Both proteins have been implicated as essential proteins for skin barrier maintenance.
Rahrig, Sebastian
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Redox Biology, 2020 Since the skin is one of the targets of the harmful effects of environmental insults, several studies have investigated the effects of outdoor stressors on cutaneous tissue.
Francesca Ferrara +8 more
doaj +1 more source