Results 81 to 90 of about 6,491,911 (254)
Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen [PDF]
Journal of Allergy and Clinical Immunology, 2009 Filaggrin is important for skin barrier function and is mutated in 15% to 20% of patients with atopic dermatitis.To examine whether filaggrin deficiency predisposes to skin inflammation and epicutaneous sensitization with protein antigen.Skin histology in filaggrin-deficient flaky tail (ft)/ft mice and wild-type controls was assessed by Hematoxylin and
Michiko K, Oyoshi +2 more
openaire +2 more sources
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
Central Asian Journal of Medical SciencesObjective: The complex interplay between genetic and external factors contributes to the multifactorial nature of atopic dermatitis (AD). The study aimed to use next-generation sequencing (NGS) to identify and describe genetic alterations and ...
Lkhamdari Batbileg +5 more
doaj +1 more source
Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients [PDF]
, 2018 Background: Sepsis is a life-threatening illness with a challenging diagnosis. Current serum biomarkers are not sensitive enough for diagnosis. With the aim of finding proteins associated with sepsis, serum protein profile was compared between patients ...
Astigarraga Aguirre, María Iciar +7 more
core +3 more sources
Scientific Reports, 2021 Atopic dermatitis (AD) is one of the most common skin diseases of dogs. Defects in the skin barrier and overproduction of inflammatory cytokines may be the pathogenesis of canine AD.
Sarita Kanwal +6 more
semanticscholar +1 more source
The Journal of Dermatology, EarlyView.ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory dermatitis underpinned by Type 2 inflammation driven by cytokines such as IL‐4 and IL‐13. It is characterized by skin barrier dysfunction, Th2 immune deviation, and pruritus. While biologics and oral Janus kinase (JAK) inhibitors demonstrate high therapeutic efficacy by targeting cytokines that ...
Gaku Tsuji +7 more
wiley +1 more source
Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food
Allergy, EarlyView.ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy +7 more
wiley +1 more source
Redox Biology, 2020 Since the skin is one of the targets of the harmful effects of environmental insults, several studies have investigated the effects of outdoor stressors on cutaneous tissue.
Francesca Ferrara +8 more
doaj +1 more source
Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
Exploration of Immunology, 2021 Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2).
Masutaka Furue, Mihoko Furue
doaj +1 more source
Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families [PDF]
, 2008 Recent studies have identified 2 loss-of-function variants, R501X and 2282del4, in the filaggrin gene as predisposing factors in the development of eczema.
Bradley, Maria +7 more
core +3 more sources