Results 71 to 80 of about 7,455 (218)

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Interaction between extracellular matrix molecules and microbial pathogens: evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model. [PDF]

, 2014
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation followed by tissue rebuilding or fibrosis. A failure by the body to regulate inflammation effectively is one of the hallmarks of RA.
Saralili Dipa Robertson, Nidhi eSofat, Robertson, Saralili D, Baines, DL, Wait, R, Robertson, SD, Wait, Robin, Robin eWait, Emma Harriet Baker, Baines, Deborah L, Deborah eBaines, Deborah L. Baines, Sofat, N, Baker, EH, Nidhi Sofat, Saralili D. Robertson, Emma H. Baker, Sofat, Nidhi, Baker, Emma H, Robin Wait   +19 more
core   +2 more sources

The role of interleukin-24 in atopic dermatitis

Exploration of Immunology, 2021
Atopic dermatitis (AD) is characterized by skin barrier disruption, type 2 immune dysregulation, chronic pruritus, and abnormal colonization by Staphylococcus aureus (S. aureus). Tapinarof, an aryl hydrocarbon receptor modulator, has been demonstrated to
Yen Hai Vu, Masutaka Furue, Gaku Tsuji
doaj   +1 more source

Keratinocyte Priming by Staphylococcus aureus Reduces HSV‐1 Susceptibility

Allergy, EarlyView.
ADEH+ patients have a reduced microbial diversity with increased S. aureus and S. epidermidis colonization compared to ADEH− and healthy controls. Heat‐killed S. aureus reduced HSV‐1 susceptibility and release of infectious progeny virus in a keratinocyte in vitro model. Heat‐killed S.
Phila Cara Baumann, Rebecca Pospich, Katinka Döhner, Ilona Klug, Julio Cesar Villalvazo Guerrero, Jan Hartmann, Inken Harder, Wolfgang Lieb, Barbara Kind, Andreas Kleinheinz, Susanne Abraham, Matthias Augustin, Elke Weisshaar, Jochen Schmitt, Stephan Weidinger, Beate Sodeik, Thomas Werfel, Lennart M. Roesner, Stephan Traidl, The TREATgermany Study Group   +19 more
wiley   +1 more source

Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes [PDF]

, 2010
Sphingosylphosphorylcholine (SPC) mediates various inflammatory and behavioral responses in atopic dermatitis. Recent studies have shown that dysfunction of the epidermal permeability barrier itself plays a primary role in the etiology of atopic ...
Kim, Kwang-Mi, Kim, Hyoung-June, Noh, Minsoo, Lee, Chang-Hoon, Shin, Jennifer Hyunjong, Choi, Hyun, Kim, Shinhyoung   +6 more
core   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Expression of Skin Barrier Protein Filaggrin in Skin Diseases without Atopic Dermatitis

Journal of Biosciences and Medicines, 2018
The epidermis represents an essential barrier versus a broad range of exogenous stimuli. To form a functional epidermis, keratinocytes express filaggrin which plays a vital role in atopic dermatitis. However the relationship between filaggrin and other skin diseases remains unknown.
Yang Zhang, Chen Tu, Shuang Wang, Shengxiang Xiao   +3 more
openaire   +2 more sources

PDE4 inhibition by difamilast regulates filaggrin and loricrin expression via keratinocyte proline-rich protein in human keratinocytes

Journal of Dermatological Science, 2023
Difamilast, a topical phosphodiesterase 4 (PDE4) inhibitor, has been shown to be effective for treating atopic dermatitis (AD), but the molecular mechanism involved is unclear. Since skin barrier dysfunction including reduced expression of filaggrin (FLG) and loricrin (LOR) contributes to AD development, difamilast treatment may be able to improve this
Gaku, Tsuji, Akiko, Hashimoto-Hachiya, Ayako, Yumine, Masaki, Takemura, Makiko, Kido-Nakahara, Takamichi, Ito, Kazuhiko, Yamamura, Takeshi, Nakahara   +7 more
openaire   +2 more sources

Ichthyosis Vulgaris: Identification of a Defect in Synthesis of Filaggrin Correlated with an Absence of Keratohyaline Granules [PDF]

, 1985
Ichthyosis vulgaris is an autosomal dominant disorder of keratinization characterized histologically by absent or reduced keratohyaline granules in the epidermis and mild hyperkeratosis. The basic defect in ichthyosis vulgaris is unknown.
Sybert, Virginia P, Dale, Beverly A, Holbrook, Karen A   +2 more
core   +1 more source

Genetic Susceptibility Factors for Eczema [PDF]

, 2011
Eczema (atopic dermatitis) is one of the most common chronic inflammatory skin diseases in infants and children with prevalence rates of up to 20%. The disease frequently co-occurs with other atopic disorders such as asthma and rhinitis and is often ...
Rodriguez, Elke, Rodriguez, E.
core