Results 81 to 90 of about 467,385 (295)

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Stakeholder Perspectives on Therapeutic and Safe Building Design in Residential Care

Australian Journal of Social Issues, EarlyView.
ABSTRACT Residential care is a form of out‐of‐home care that plays a critical role in supporting vulnerable young people in Australia. However, there is an evidence gap regarding the built environment in this context. This research aimed to explore the perspectives of key stakeholders in residential care in Victoria, Australia, regarding design that ...
Carmen Schroder, Olivia Crivari, Phillippa Carnemolla, Libby Callaway   +3 more
wiley   +1 more source

Operant Reinforcement and Development of Emotion Dysregulation

, 2018
Caregivers play a foundational role in the development of children’s emotion dysregulation. Yet, because there are a multitude of ways in which parent behavior can intersect with children’s emotions, the development of emotion dysregulation is complex ...
Maureen Zalewski, Christina Gamache Martin, Grace Binion, Jacqueline O’Brien   +3 more
core   +1 more source

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

Associations between trauma and substance use among healthcare workers and public safety personnel during the SARS-CoV-2 (COVID-19) pandemic: the mediating roles of dissociation and emotion dysregulation

European Journal of Psychotraumatology, 2023
Background: Given the highly stressful environment surrounding the SARS-CoV-2 pandemic, healthcare workers (HCW) and public safety personnel (PSP) are at an elevated risk for adverse psychological outcomes, including posttraumatic stress disorder (PTSD ...
Herry Patel, Bethany Easterbrook, Andrea M. D'Alessandro-Lowe, Krysta Andrews, Kimberly Ritchie, Fardous Hosseiny, Sara Rodrigues, Ann Malain, Charlene O’Connor, Hugo Schielke, Randi E. McCabe, Andrew A. Nicholson, Ruth Lanius, Margaret C. McKinnon   +13 more
doaj   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Emotion dysregulation in insomnia disorder: the possible role of psychiatric comorbidity

Frontiers in Sleep
AimThe purpose of this study was to investigate the link between emotion dysregulation and insomnia disorder as well as the possible role of psychiatric comorbidity on the association.
Markus Jansson-Fröjmark, Samiul Hossain
doaj   +1 more source

Food addiction and binge eating disorder are linked to shared and unique deficits in emotion regulation among female seeking bariatric surgery

Journal of Eating Disorders, 2023
Background Problematic eating behaviors can indicate obesity-related problems. Food addiction (FA) is not classified as an official diagnosis. However, given the many commonalities between FA and binge-eating disorder (BED) within the context of obesity,
Shahrzad Ahmadkaraji, Hojjatollah Farahani, Koosha Orfi, Fahimeh Fathali Lavasani   +3 more
doaj   +1 more source

Positive Emotion Dysregulation: A Metacognitive Perspective. [PDF]

Clin Psychol Psychother
ABSTRACT Introduction Using the metacognitive model of emotion dysregulation as a basis, this study explored whether metacognitive beliefs are associated with positive emotion dysregulation. Method
Mansueto G, Palmieri S, Salatini L, Piccioni S, Ruggiero GM, Sassaroli S, Spada MM, Caselli G.   +7 more
europepmc   +4 more sources

Control in Intimate Relationships: An Exploration of Insecure Attachment Styles, Emotion Dysregulation, and Shame-Proneness

Purpose In the extant literature on Intimate Partner Violence, control in intimate relationships remains relatively under-explored. In the current study, we explore the utility of insecure attachment styles (i.e., anxious attachment and avoidant ...
March, Evita, Walls, Kylie L., Marrington, Jessica Z.   +2 more
core   +1 more source