Results 61 to 70 of about 125,087 (294)
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei+18 more
wiley +1 more source
Clinical overview on RASopathies
Abstract RASopathies comprise a group of clinically overlapping developmental disorders caused by genetic variations affecting components or modulators of the RAS‐MAPK signaling cascade, which lead to dysregulation of signal flow through this pathway.
Martin Zenker
wiley +1 more source
Autism spectrum disorder (ASD) often co-occurs with functional somatic syndromes (FSS), such as irritable bowel syndrome (IBS), multisite pain, and fatigue. However, the underlying genetic mechanisms and causality have not been well studied.
Yiran Li+4 more
doaj +1 more source
Large‐Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain
This study delineates both common and site‐specific proteins linked to various chronic pain conditions, elucidating their implications across molecular pathways and health status. These findings, particularly those proteins with genetic causal links to pain or predictive capabilities, have the potential to significantly benefit both research and ...
Ze‐Yu Li+17 more
wiley +1 more source
Abstract Gene variants that dysregulate signaling through the RAS‐MAPK pathway cause cardiofaciocutaneous syndrome (CFCS), a rare multi‐system disorder. Infantile epileptic spasms syndrome (IESS) and other forms of epilepsy are among the most serious complications.
Daniel L. Kenney‐Jung+14 more
wiley +1 more source
Background The Four-Dimensional Symptom Questionnaire (4DSQ) (Huisarts Wetenschap 39: 538–47, 1996) is a self-report questionnaire developed in the Netherlands to distinguish non-specific general distress from depression, anxiety, and somatization.
Jan van Bebber+9 more
doaj +1 more source
Designing for emotion regulation interventions: an agenda for HCI theory and research [PDF]
There is a growing interest in HCI to envision, design, and evaluate technology-enabled interventions that support users' emotion regulation. This interest stems in part from increased recognition that the ability to regulate emotions is critical to mental health, and that a lack of effective emotion regulation is a transdiagnostic factor for mental ...
arxiv
Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley +1 more source
A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis
The dynamic interplay between central respiratory chemoreceptors and the respiratory central pattern generator is essential for maintaining stable respiratory rhythm and patterns, particularly during sleep. This study offers novel insights into the anatomical, molecular, and functional characteristics of a medullary network involving the nucleus ...
Tianjiao Deng+16 more
wiley +1 more source
Abstract Family and domestic violence (FDV) is a major social, economic and health issue that is associated with a range of physical, mental and behavioural health outcomes. Religion and faith are powerful and influential in shaping the lives of many individuals and societies, in addition to the social practices, norms and structures that are ...
Mandy Truong+5 more
wiley +1 more source