Results 51 to 60 of about 65,528 (262)

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Animal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu, Yafei Yang, Chunxi Liu, Danting Wen, Tingyu Zhao, Ping Xie, Jing Xiao   +6 more
wiley   +1 more source

Overlaps and differences in the core symptoms of patients with attention-deficit/hyperactivity disorder and patients with borderline personality disorder

Frontiers in Psychiatry
BackgroundIndividuals with attention-deficit/hyperactivity disorder (ADHD) and individuals with borderline personality disorder (BPD) show symptomatic overlaps.
Anna Christen, Anna Christen, Marialuisa Cavelti, Rolf-Dieter Stieglitz, Beatrice Abt-Mörstedt, Hannes Bitto, Patricia E. Newark, Patricia E. Newark, Franz Moggi, Kerstin Gabriel Felleiter, Niklaus Stulz, Andreas Riedel, Salvatore Corbisiero, Salvatore Corbisiero   +13 more
doaj   +1 more source

Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Animal Models and Experimental Medicine, EarlyView.
Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee, Yoongeun Kim, Hyungjun Kim, Dae‐Hyun Hahm   +3 more
wiley   +1 more source

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

Animal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan, Ruiguang Huang, Shuqiong Cao, Luxia Pan, Wenkai Zhang, Wujun Jiang, Zhiyong Liu   +6 more
wiley   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Does perceived emotional invalidation moderate the link between specific types of childhood traumas and emotion dysregulation in predicting psychological distress?

Acta Psychologica
Although emotion dysregulation has been established as a mediator between childhood traumas (CTs) and psychological distress, there is limited knowledge about the moderating role of perceived emotional invalidation (PEI) in the relationship between ...
Mehdi Rezaei, Zahra Paripishbar, Samaneh Khazaei   +2 more
doaj   +1 more source

Change Trajectories During Parent–Child Interaction Therapy for Autistic Children and Their Caregivers

Autism Research, EarlyView.
ABSTRACT Disruptive behaviors (non‐compliance, aggression) are common in autistic children. Parent–Child Interaction Therapy (PCIT) is a caregiver‐mediated intervention utilizing in vivo caregiver coaching that reduces disruptive behaviors and has been shown to be effective for young autistic children.
Catherine A. Burrows, William Andrew Rothenberg, Dainelys Garcia, Abigail Peskin, Maria Jimenez‐Muñoz, Eileen Davis, Jason F. Jent, Meaghan V. Parladé   +7 more
wiley   +1 more source

Parenting strategies: how they affect adolescents’ degree of life satisfaction

Journal of Clinical & Developmental Psychology, 2020
Background: According to Self Determination Theory (SDT) emotional self-regulation is a process of gradual acquisition of autonomous regulation capacity, which is influenced by both individual differences and social context in which the person is ...
Ilaria Meneghini, Claudia Aloisi, Clara Alosi, Liliana Arena, Valeria Barbagallo, Gabriele Berretta, Moira Biviano, Selene Billa, Maria Teresa Blando, Erika Bonaccorso, Marika Bottino, Lorenza Camarda, Nives Miriam Cassone, Ludovica Cerbone, Andrea Citrigno, Mihaela Kati Corsaro, Ludovica Corvaia, Chiara Costantino, Domenico Cotrone, Francesca Cutrì   +19 more
doaj   +1 more source

A Network Analysis of Alexithymia, Interoception, Empathy, Self‐Awareness and Psychopathological Symptoms in Young People With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with altered interoception, empathy, self‐awareness, and alexithymia. However, limited research has been conducted to investigate the interrelationships of these constructs with psychopathological symptoms.
Antonio Kei‐Fung Shek, Simon S. Y. Lui, Eric C. L. Lai, Raisie W. K. Wong, Jason L. F. Chan, Lok‐Yin Choi, Kimi H. Y. Lam, Eugenia Y. C. Lok, Siu‐Man Lam, Wang Yi, Raymond C. K. Chan   +10 more
wiley   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source