Results 61 to 70 of about 72,254 (298)

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Emotional dysregulation in adult ADHD [PDF]

, 2019
Aktiivisuuden ja tarkkaavuuden häiriö (engl. attention deficit hyperactivity disorder, ADHD) on lapsuusiässä alkava aivojen kehityksellinen häiriö. Sen pysyvyyden aikuisuudessa on arvioitu olevan 4-70 %. ADHD:n diagnostisia oireita ovat tarkkaamattomuus,
Puhakka, Jasmin
core  

A controlled study of emotional dysfunction in adult women with ADHD.

PLoS ONE
ObjectiveGiven the increased socio-emotional burden of ADHD symptoms in women, the current study examined the associations between ADHD symptoms, emotional dysregulation, and executive function deficits.
Ortal Slobodin, Michal Har Sinay, Ada H Zohar   +2 more
doaj   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Food addiction and binge eating disorder are linked to shared and unique deficits in emotion regulation among female seeking bariatric surgery

Journal of Eating Disorders, 2023
Background Problematic eating behaviors can indicate obesity-related problems. Food addiction (FA) is not classified as an official diagnosis. However, given the many commonalities between FA and binge-eating disorder (BED) within the context of obesity,
Shahrzad Ahmadkaraji, Hojjatollah Farahani, Koosha Orfi, Fahimeh Fathali Lavasani   +3 more
doaj   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Emotional dysregulation in psychosis – proof of concept in healthy controls [PDF]

, 2017
Objectives: Psychosis symptoms occur in around 1-2% of the population during their lifetime. Various psychosis symptoms relate to a disturbed perception and regulation of emotions.
Furger, Stephan, Wiest, Roland, Walther, Sebastian, Papmeyer, Martina, Zengaffinen, Francilia Sabrina, Rapp, Charlotte, Nick, Beat, Dierks, Thomas, Stegmayer, Katharina, Federspiel, Andrea, Stahnke, Antje, König, Thomas, Strik, Werner, Hatzinger, Martin   +13 more
core  

The Relationship Between Distress Intolerance, Emotional Dysregulation, and Social Networking Site Addiction [PDF]

, 2021
The use of social networking sites (SNSs) continues to increase. SNS addiction refers to the maladaptive behaviors associated with addiction and the use of SNSs. The purpose of this study was to examine the association between emotional dysregulation and
Nozaki, Matthew
core   +1 more source

The Correlation Between Emotional Dysregulation and Deliberate Self-harm Among College Students in Malang [PDF]

, 2022
This study aimed to examine the correlation between emotional dysregulation and self-harm behavior among college students in Malang city. The research topic was based on the phenomenon of self-harm among college students.
Citra Tristania, Olifia, Hanurawan, Fattah   +1 more
core   +2 more sources

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source