Results 111 to 120 of about 6,553,167 (295)

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Ageing and emotion regulation

, 2009
The thesis commences with a review of trends in declining psychological disorders as a person ages. These findings are understood in terms of differences between older andyounger adults’ emotion processing.
Brümmer, Laura
core   +1 more source

Commentary: Putting ‘Emotional Intelligences' in Their Place: Introducing the Integrated Model of Affect-Related Individual Differences

Frontiers in Psychology, 2020
Pablo Ezequiel Flores Kanter, Leonardo Adrián Medrano   +1 more
doaj   +1 more source

Independent and collaborative contributions of the cerebral hemispheres to emotional processing

Frontiers in Human Neuroscience, 2014
Presented is a model suggesting that the RH directly mediates the identification and comprehension of positive and negative emotional stimuli, whereas the LH contributes to higher level processing of emotional information that has been shared via the ...
Elizabeth R Shobe
doaj   +1 more source

Experiential Avoidance Mediates the Association between Emotion Regulation Abilities and Loneliness

PLOS ONE, 2016
Experiential avoidance (EA) involves the unwillingness to remain in contact with aversive experiences such as painful feelings, thoughts, and emotions. EA is often associated with the development and maintenance of emotional problems. Since loneliness is characterized by negative emotions such as sadness and pessimism, which is often linked to ...
Rui Shi, Shilei Zhang, Qianwen Zhang, Shaoping Fu, Zhenhong Wang   +4 more
openaire   +4 more sources

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Benchmark for evaluating emotional regulation ability of large language model

Tongxin xuebao
To address the lack of emotional regulation assessment in current evaluations of large language model (LLM), an evaluation benchmark for assessing emotional regulation capabilities in LLM was proposed.
MA Zhiqiang, LIU Yixing, LIU Jia, LI Xin
doaj  

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Awareness of Emotion Expression Rules in Older Preschoolers: Diagnostics of Cognitive and Behavioral Components

Вопросы образования
Psychological research has established a link between the development of emotion regulation in older preschool children and the growth of their understanding of emotions.
Olga S. Pavlova
doaj   +1 more source