Results 41 to 50 of about 8,573,374 (325)

Bladder Pain Syndrome: A Review

European Medical Journal Urology, 2020
Therapy of bladder pain syndrome (BPS) presents a significant challenge in clinical practice. Over the last 20 years, there have been important efforts directed at understanding the syndrome’s aetiology and therapeutic challenges.
Gokhan Calik, Jean de la Rosett
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Inequalities in the geographic access to delivery services in Brazil

BMC Health Services Research
Background Despite Brazil’s recent social progress, access to health services is still unequal. This article analyzes the inter-municipal distances traveled by pregnant women to access delivery services, documenting their magnitude and relationship to ...
Valdemar Pinho Neto, Cecilia Machado, Felipe Lima, Soraya Roman, Gilson Dutra   +4 more
doaj   +1 more source

Discovering qualitative empirical laws [PDF]

, 1985
In this paper we describe GLAUBER, an AI system that models the scientific discovery of qualitative empirical laws. We have tested the system on data from the history of early chemistry, and it has rediscovered such concepts as acids, alkalis, and salts,
Fisher, Douglas H., Langley, Pat, Simon, Herbert A., Zytkow, Jan M.   +3 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A Commentary on Poudrier's "Tapping to Carter: Mensural Determinacy in Complex Rhythmic Sequences"

Empirical Musicology Review, 2018
This paper is a brief commentary on Poudrier's (2017) research article titled "Tapping to Carter: Mensural Determinacy in Complex Rhythmic Sequences." Poudrier's study aimed "to explore the relative salience of an implied beat in two contrasting rhythmic
Timo Fischinger, Annette van Dyck-Hemming   +1 more
doaj   +1 more source

Empirical interpretation of imprecise probabilities [PDF]

, 2017
This paper investigates the possibility of a frequentist interpretation of imprecise probabilities, by generalizing the approach of Bernoulli’s Ars Conjectandi.
Cattaneo, Marco
core  

Risk aggregation with empirical margins: Latin hypercubes, empirical copulas, and convergence of sum distributions

, 2015
This paper studies convergence properties of multivariate distributions constructed by endowing empirical margins with a copula. This setting includes Latin Hypercube Sampling with dependence, also known as the Iman--Conover method.
Mainik, Georg
core   +1 more source