Results 51 to 60 of about 6,221,821 (301)

The anticipation of events in time

Nature Communications, 2019
The brain predicts upcoming events—a fundamental operation assumed to depend on the event hazard rate and a linearly increasing uncertainty in time estimation.
Matthias Grabenhorst, Georgios Michalareas, Laurence T. Maloney, David Poeppel   +3 more
doaj   +1 more source

Establishment and Characterization of an Empirical Biomarker SS/PV-ROC Plot Using Results of the UBC^® Rapid Test in Bladder Cancer

Entropy, 2020
Background: This investigation included both a study of potential non-invasive diagnostic approaches for the bladder cancer biomarker UBC® Rapid Test and a study including comparative methods about sensitivity–specificity characteristic (SS-ROC) and ...
Peter Oehr, Thorsten Ecke
doaj   +1 more source

NRLMSIS 2.0: A Whole‐Atmosphere Empirical Model of Temperature and Neutral Species Densities

Earth and Space Science, 2021
NRLMSIS® 2.0 is an empirical atmospheric model that extends from the ground to the exobase and describes the average observed behavior of temperature, eight species densities, and mass density via a parametric analytic formulation.
J. T. Emmert, D. P. Drob, J. M. Picone, D. E. Siskind, M. Jones Jr., M. G. Mlynczak, P. F. Bernath, X. Chu, E. Doornbos, B. Funke, L. P. Goncharenko, M. E. Hervig, M. J. Schwartz, P. E. Sheese, F. Vargas, B. P. Williams, T. Yuan   +16 more
doaj   +1 more source

Empirical Negation [PDF]

Acta Analytica, 2012
An extension of intuitionism to empirical discourse, a project most seriously taken up by Dummett and Tennant, requires an empirical negation whose strength lies somewhere between classical negation (‘It is unwarranted that. . . ’) and intuitionistic negation (‘It is refutable that. . . ’).
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Genetic Phenomenology and Empirical Naturalism [PDF]

, 2018
Husserl’s phenomenology is developed in explicit contrast to naturalism. At the same time, various scholars have attempted to overcome this opposition by naturalizing consciousness and phenomenology.
Pace Giannotta, Andrea
core  

Bayesian computation via empirical likelihood

, 2012
Approximate Bayesian computation (ABC) has become an essential tool for the analysis of complex stochastic models when the likelihood function is numerically unavailable.
Beaumont, Chan, Christian P. Robert, Estoup, Fearnhead, Hudson, Kerrie L. Mengersen, Kim, Lopes, McVean, Ohta, Pierre Pudlo, Pritchard, Tavaré, Wilson   +14 more
core   +4 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Social processing distorts physical distance perception

Scientific Reports
Psychopathy is traditionally linked to higher-level cognitive processes, but its impact on low-level cognitive functions has remained largely unexplored.
Georgios Michalareas, Claudia Lehr, Matthias Grabenhorst, Heiko Hecht   +3 more
doaj   +1 more source