Results 41 to 50 of about 6,221,821 (301)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Types of Privacy Expectations

open access: yesFrontiers in Big Data, 2020
Understanding user privacy expectations is important and challenging. General Data Protection Regulation (GDPR) for instance requires companies to assess user privacy expectations. Existing privacy literature has largely considered privacy expectation as
Ashwini Rao, Juergen Pfeffer
doaj   +1 more source

Empirical consequences of symmetries [PDF]

open access: yes, 2011
`Global' symmetries, such as the boost invariance of classical mechanics and special relativity, can give rise to direct empirical counterparts such as the Galileo-ship phenomenon. However, a widely accepted line of thought holds that `local' symmetries,
Greaves, Hilary, Wallace, David
core   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

A Commentary on Poudrier's "Tapping to Carter: Mensural Determinacy in Complex Rhythmic Sequences"

open access: yesEmpirical Musicology Review, 2018
This paper is a brief commentary on Poudrier's (2017) research article titled "Tapping to Carter: Mensural Determinacy in Complex Rhythmic Sequences." Poudrier's study aimed "to explore the relative salience of an implied beat in two contrasting rhythmic
Timo Fischinger   +1 more
doaj   +1 more source

Discovering qualitative empirical laws [PDF]

open access: yes, 1985
In this paper we describe GLAUBER, an AI system that models the scientific discovery of qualitative empirical laws. We have tested the system on data from the history of early chemistry, and it has rediscovered such concepts as acids, alkalis, and salts,
Fisher, Douglas H.   +3 more
core   +1 more source

Empirical pseudopotential calculations of Cd1-xMnxTe [PDF]

open access: yes, 1996
Empirical pseudopotential calculations for the entire range of alloy concentrations of cubic Cd(1-x)Mn(x)Te are presented. The atomic form factors have been deduced empirically by fitting the band structure to spectroscopic data available from the ...
Hagston, W.E., Harrison, P., Long, F.
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Empirical Bayes conditional density estimation

open access: yes, 2015
The problem of nonparametric estimation of the conditional density of a response, given a vector of explanatory variables, is classical and of prominent importance in many prediction problems since the conditional density provides a more comprehensive ...
Scricciolo, Catia
core   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

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