Results 51 to 60 of about 8,573,374 (325)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Frontiers in Big Data, 2020 Understanding user privacy expectations is important and challenging. General Data Protection Regulation (GDPR) for instance requires companies to assess user privacy expectations. Existing privacy literature has largely considered privacy expectation as
Ashwini Rao, Juergen Pfeffer
doaj +1 more source
Kant's empirical moral philosophy [PDF]
, 2003 I argue that Kant took from Moses Mendelssohn the idea of a distinction between geometry of morals and a practical ethic. He was drastically misunderstood by his followers precisely on this point.
Cremaschi, Sergio Volodia Marcello
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Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
The anticipation of events in time
Nature Communications, 2019 The brain predicts upcoming events—a fundamental operation assumed to depend on the event hazard rate and a linearly increasing uncertainty in time estimation.
Matthias Grabenhorst +3 more
doaj +1 more source
Acta Analytica, 2012 An extension of intuitionism to empirical discourse, a project most seriously taken up by Dummett and Tennant, requires an empirical negation whose strength lies somewhere between classical negation (‘It is unwarranted that. . . ’) and intuitionistic negation (‘It is refutable that. . . ’).
openaire +2 more sources
Empirical Consequences of Comparable Worth [PDF]
, 1989 [Excerpt] To help focus subsequent debate, this paper presents a nontechnical survey of the small but growing empirical literature by economists on the consequences of comparable worth. I discuss in turn studies of the consequences of comparable worth on
Ehrenberg, Ronald G
core +1 more source
Bayesian computation via empirical likelihood
, 2012 Approximate Bayesian computation (ABC) has become an essential tool for the analysis of complex stochastic models when the likelihood function is numerically unavailable.
Beaumont +14 more
core +4 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Colonialism and Industrialization: Empirical Results [PDF]
, 1998 This paper presents theory and evidence to show that imperialism was a major factor impeding the spread of the industrial revolution during the century ending in the 1950s. Two empirical results stand out.
Alam, M. Shahid
core