Results 61 to 70 of about 184,299 (283)

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

A second-order efficient empirical Bayes confidence interval

, 2014
We introduce a new adjusted residual maximum likelihood method (REML) in the context of producing an empirical Bayes (EB) confidence interval for a normal mean, a problem of great interest in different small area applications.
Lahiri, Partha, Yoshimori, Masayo
core   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

A Dynamic Empirical Bayes Signal Model for Attribute Defect Detection

Signals
This study evaluates Empirical Bayes (EB) c-charts for monitoring count-type data under precautionary (PLF) and logarithmic (LLF) loss functions.
Yadpirun Supharakonsakun
doaj   +1 more source

On empirical Bayes estimation of multivariate regression coefficient

International Journal of Mathematics and Mathematical Sciences, 2006
We investigate the empirical Bayes estimation problem of multivariate regression coefficients under squared error loss function. In particular, we consider the regression model Y=Xβ+ε, where Y is an m-vector of observations, X is a known m×k matrix, β is
R. J. Karunamuni, L. Wei
doaj   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Empirical Bayes Estimation in Multiple Linear Regression with Multivariate Skew-Normal Distribution as Prior

Journal of Mathematical Extension, 2011
We develop a new empirical Bayes analysis in multiple regression models. In the present work we consider multivariate skewnormal as prior for coefficients of the model in a skew-normal population and give empirical Bayes estimation for parameters of ...
M. Khounsiavash, T. Baghfalaki, M. Ganjali   +2 more
doaj  

Are Safety Corridors Effective in Mitigating Safety? An Ohio-Based Case Study Evaluating Their Effectiveness

Vehicles
Distracted driving remains a major concern on highways, with it contributing to severe and fatal crashes, particularly on high-speed routes, prompting numerous states to implement targeted initiatives aimed at combating traffic violations that ...
Sudesh Ramesh Bhagat, Bernard Ndeogo Issifu, Devon Destocki, Bhaven Naik, Deogratias Eustace   +4 more
doaj   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Flexible Modeling of Epidemics with an Empirical Bayes Framework. [PDF]

PLoS Computational Biology, 2015
Seasonal influenza epidemics cause consistent, considerable, widespread loss annually in terms of economic burden, morbidity, and mortality. With access to accurate and reliable forecasts of a current or upcoming influenza epidemic's behavior, policy ...
Logan C Brooks, David C Farrow, Sangwon Hyun, Ryan J Tibshirani, Roni Rosenfeld   +4 more
doaj   +1 more source