Results 41 to 50 of about 608,244 (260)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

On the Growing Role of Observation, Formalization and Experimental Method in Musicology

open access: yesEmpirical Musicology Review, 2006
In the last two decades an important shift has occurred in music research, that is, from music as an art (or art object) to music as a process in which the performer, the listener, and music as sound play a central role.
Henkjan Honing
doaj   +1 more source

On the Empirical Validity of the Bayesian Method

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 1993
SUMMARY The ideas in Kolmogorov's programme for algorithmic substantiation of applications of probability make it possible to define a measure of disagreement between the probability distribution representing the attitude of a coherent individual towards a random experiment and the outcome of the experiment.
Vovk, V. G., V'yugin, V. V.
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Concept Analysis as Empirical Method

open access: yesInternational Journal of Qualitative Methods, 2002
Although there is not much support anymore for a clear cut distinction between object-language and meta-language, the view is generally accepted that the outcomes of concept analysis concern knowledge of the structures of language and not knowledge of ...
Bas Levering
doaj   +1 more source

Etkin Yağış Metotlarının Kıyaslaması: Orta Fırat Havzası Örneği

open access: yesCoğrafi Bilimler Dergisi, 2022
Precipitation is one of the climate parameters with the widest effects. Not all precipitation seeps into the ground; some may evaporate; another part may turn into the runoff.
Gülşen KUM
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

The Potential of the Internet for Music Perception Research: A Comment on Lab-Based Versus Web-Based Studies

open access: yesEmpirical Musicology Review, 2008
While the discussion on the integrity of data obtained from Web- delivered experiments is mainly about issues of method and control (Mehler, 1999; McGraw et al., 2000; Auditory, 2007), this comment stresses the potential that Web- based experiments might
Henkjan Honing, Olivia Ladinig
doaj   +1 more source

Cavitation Prevention for Submarine Propeller with Empirical Method

open access: yesKapal, 2023
Submarines are a component that is taken into account in assessing the security of a country. Many countries have developed their own types of submarines according to technological developments in that country. To be able to move silently underwater, the
Riyan Bagus Prihandanu, Achmad Baidowi
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

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