Results 51 to 60 of about 1,978,218 (342)

Converging to efficiency : the Ramón y Cajal Program experience [PDF]

, 2007
We analyze the evolution on the design of a policy measure promoted by the Spanish Government: the Ramón y Cajal Program. In the first calls of the Program, an eligibility requirement for a researcher was a preacceptance from at least one Spanish ...
Alonso-Borrego, César, Romero-Medina, Antonio, Triossi, Matteo   +2 more
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Next generation software environments : principles, problems, and research directions [PDF]

, 1987
The past decade has seen a burgeoning of research and development in software environments. Conferences have been devoted to the topic of practical environments, journal papers produced, and commercial systems sold.
Baker, Deborah A., Belz, Frank C., Boehm, Barry W., Clarke, Lori A., Fisher, David A., Osterweil, Leon, Selby, Richard W., Taylor, Richard N., Wileden, Jack C., Wolf, Alexander L., Young, Michal   +10 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

An exploration and description of experiences of at-risk youth in a correctional center in Eswatini regarding a resilience intervention program

Frontiers in Psychology, 2022
Resilience-focused programs advocate nurturing positive adoptive traits to inform prevention and intervention efforts. Considering that no resilience intervention programs have been developed specifically for at-risk youth in correctional centers in ...
Sifiso B. Shabangu, Vicki Koen
doaj   +1 more source

Improving the viability of mental models held by novice programmers [PDF]

, 2007
Recent research has found that many novice programmers often hold non-viable mental models of basic programming concepts such as assignment and object reference.
Ferguson, J., Ma, L., Roper, M., Wood, M.   +3 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

From Anti-equilibrium to The Socialist System and Beyond [PDF]

, 2013
This essay attempts to understand János Kornai’s works from a political economy perspective. It argues that Kornai has significantly contributed to the formation of a new paradigm of political economy. The main endeavor of Kornai has been the combination
Acemoglu D., Acemoglu D., Acemoglu D., Chikán A., Hayek F. A., Hayek F. A., Hámori B., Kornai J., Kornai J., Kornai J., Kornai J., Kornai J., Kornai J., Kornai J., Kornai J., Kornai J., Kornai J., Kornai J., Leeson P. T., Mann T., Menger C., North D. C., North D. C., North D. C., Péter Gedeon   +24 more
core   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source