Results 41 to 50 of about 1,608,470 (307)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
An Empirical Study of Cohesion and Coupling: Balancing Optimisation and Disruption [PDF]
, 2018 Search based software engineering has been extensively applied to the problem of finding improved modular structures that maximise cohesion and minimise coupling.
Yuanyuan Zhang +11 more
core +1 more source
GenusThe increase in inequalities during the ongoing COVID-19 pandemic has been the topic of intense scholarly and public debate. School closures are one of the containment measures that have been debated most critically in this regard.
Luna Bellani +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Volition and control in law and in brain science: neurolegal translation of a foundational concept
Frontiers in Human NeuroscienceThe law assumes that healthy adults are generally responsible for their actions and have the ability to control their behavior based on rational and moral principles.
Julia F. Christensen +4 more
doaj +1 more source
Analysis of the Macroscopic Behavior of Server Systems in the Internet Environment
Applied Sciences, 2017 Elasticity is one of the key features of cloud-hosted services built on virtualization technology. To utilize the elasticity of cloud environments, administrators should accurately capture the operational status of server systems, which changes ...
Yusuke Tanimura +3 more
doaj +1 more source
The relation between theory and reality in Eugeniu Coșeriu and José Ortega y Gasset [PDF]
Diacronia, 2019 Taking as a starting point a quote about theory attributed to José Ortega y Gasset (1883–1955), a quote which Eugeniu Coșeriu (1921–2002) reproduced distorted in one of his lectures delivered in Romanian (in 1992), I aim—apart from identifying the ...
Cristinel Munteanu
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
A replicated empirical study of a selection method for software reliability growth models
, 2007 Replications are commonly considered to be important contributions to investigate the generality of empirical studies. By replicating an original study it may be shown that the results are either valid or invalid in another context, outside the specific ...
Lund University., Andersson, Carina,
core +1 more source