Results 71 to 80 of about 1,608,470 (307)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
衛星監控資訊作為法庭證據之實證研究―以高等以上法院裁判為中心 Satellite Surveillance Information as Evidence in the Higher Court of Taiwan [PDF]
Kējì Fǎxué Pínglùn, 2008 目前法院對於利用衛星監控資訊作為證據，已不陌生，特別是在偏遠的山區以及海面，以衛星定位、空照確認特定行為地點及其範圍，已為目前行政機關、船隻航行常用甚至必備工具。大部分的衛星定位與空照資訊多為法院認可接受成為待證事實的證據，證據證明力也相當高，雖然不乏具有排除證據適用以及欠缺證明力效果的法院裁判。整體看來，面對此一高科技產生的證據事實，法院似乎尚未能夠熟悉衛星資訊取得與應用的玄機奧妙，從而有高度接受並加以適用的結果。然而，仔細探究，部分司法警察於犯罪調查 中取得的衛星定位與個人通訊場所地理位置資訊 ...
蔡達智 Ta-Chih Tsai
doaj
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
美國、台灣與中國大陸之專利侵權民事損害賠償實證研究 An Empirical Study on the Damage Award of Patent Infringement in the U.S., Taiwan and China [PDF]
Kējì Fǎxué Pínglùn, 2009 本文針對專利侵權損害賠償制度之設計及實務上所採行的計算，進行實證研究，用以檢視制度之實施，並對相關現象提供解釋。 美國、台灣與中國大陸的法律與法院，在損害賠償計算的原理上相近，但在實務運作上有相當大之落差，其關鍵在於訴訟當事人對損害舉證的要求與法院採信的程度而定。美國專利訴訟判決自1980 年至2000 年之間，以所失利益（lost profit）為主要的計算方式（83%）。然而，自2000 年以降，採用合理權利金（reasonable royalty）之案件反而成為主流（65%）。台灣現行所採的 ...
王俊凱 Jun-Kai Wang +5 more
doaj
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
, 2022 Heteroaromatic stacking interactions help stabilize protein tertiary structure and are important in drug binding, supramolecu-lar chemistry, and materials science.
Jingjing , Yang +17 more
core +1 more source
Determinants of the knowledge diffusion process among professionals in the IT sector
Forum Scientiae Oeconomia, 2020 Today, knowledge has become dominant, creating a new dimension of the economy, a new society and a new employee. Knowledge workers have emerged as the core of a modern organisation’s staff, and their job is to convert information into knowledge.
Anna Pietruszka-Ortyl
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
empirical-contribution-archive.zip
, 2019 Empirical study of the contribution of evidence in Network meta-analysisThe archive contains all data and functions for reproducing the analysis and produce the manuscript.
Theodoros Papakonstantinou (6554228)
core +1 more source