Results 111 to 120 of about 1,841,982 (314)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Occupational injury severity among healthcare workers: a retrospective study

BMC Public Health
Background Healthcare workers (HCWs) are exposed to a multitude of hazards in the hospital environment, increasing their risks of sustaining injuries at a higher rate compared to workers in other sectors and resulting in substantial level of modified ...
Ghassan M Khairallah, Samar Al-Hajj, Hani Mowafi, Diana V Rahme, Carine J Sakr   +4 more
doaj   +1 more source

The Heterogenous Presentation of Hepatic Mucormycosis in Adults: A Case Report and Review of the Literature

Journal of Fungi
Hepatic mucormycosis is a rare but often fatal opportunistic fungal infection, primarily affecting immunocompromised patients. Herein, we report such a case from MD Anderson Cancer Center (Houston, TX, USA) and systematically review published cases in ...
Hazim Allos, Rachel S. Hicklen, Takahiro Matsuo, Javier Adachi, Sebastian Wurster, Dimitrios P. Kontoyiannis   +5 more
doaj   +1 more source

What are the Associated Risks of Employee Engagement Surveys and How Can They Be Mitigated? [PDF]

, 2018
[Excerpt] Over 50% of employers around the world use employee engagement surveys. Companies implement these surveys for the purpose of measuring employee engagement and understanding whether change needs to occur.
McAndrew, Mikaila, Ogden, Ivar
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Antifungal Activity of a Polygalacturonic and Caprylic Acid Ointment in an In Vitro, Three-Dimensional Wound Biofilm Model

Journal of Fungi
Candida colonization and biofilms are significant contributors to impaired wound healing. Consequently, improved treatments are needed to eradicate Candida biofilms in wounds.
Bahgat Z. Gerges, Joel Rosenblatt, Y-Lan Truong, Ying Jiang, Issam I. Raad   +4 more
doaj   +1 more source

Organizational Innovators: A Study of Workplace Intra-Employee Conflict Management Strategies [PDF]

, 2017
[Excerpt] Whilst the issue of intra-employee conflict is clearly one that impacts today’s organization, it is less clear how this conflict is addressed and resolved in contemporary workplaces.
Hann, Deborah, Nash, David
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Leader values as predictors of employee affect and work passion intentions [PDF]

, 2012
The purpose of this study was to examine the empirical connection between employee perceptions of their leaders’ values orientation, employee job-specific affect, and the resultant impact these two constructs have on employee work passion intentions ...
Roberts, Lyn, Zigarmi, Drea
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source