Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Micafungin induced apoptosis in Candida parapsilosis independent of its susceptibility to micafungin
Microbial Cell, 2015 We hypothesized that the cell wall inhibitor micafungin (MICA) induces apoptosis in both MICA-susceptible (MICA-S) and MICA–non-susceptible (MICA-NS) Candida parapsilosis.
Fazal Shirazi +2 more
doaj +1 more source
PENGARUH BEBAN KERJA, STRES KERJA DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN (Studi Pada Karyawan Toko Besi Musthafa di Kab. Pasuruan) [PDF]
Each company has various assumptions regarding responses to employee performance results, these responses are related to workload, work stress, and work environment.
Bustomy, Muhammad Ainus Shobah Al
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Spectrum of high-resolution computed tomography imaging in occupational lung disease
Indian Journal of Radiology and Imaging, 2013 Damage to the lungs caused by dusts or fumes or noxious substances inhaled by workers in certain specific occupation is known as occupational lung disease.
Bhawna Satija +3 more
doaj +1 more source
Perception Is Reality: How Employees Perceive What Motivates HR Practices Affects their Engagement, Behavior and Performance [PDF]
, 2011 KEY FINDINGS Espoused or intended HR practices have differential effects on employee engagement and citizenship behaviors depending on the underlying management motives employees attribute to those practices. To achieve desired organizational outcomes,
Center for Advanced Human Resource Studies
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Employee Free Choice Act: Meaningful Remedies Against Employer Coercion [PDF]
, 2005 Prepared by the AFL-CIO, this fact sheet highlights the elements of The Employee Free Choice Act (S. 842, H.R.
AFL-CIO
core +1 more source
Do employee-owned firms produce more positive employee behavioural outcomes? If not why not? A British-Spanish comparative analysis [PDF]
, 2017 Whether ‘employee ownership’ takes the form of worker cooperatives, co-ownership or simply employee share ownership plans, there are normally high expectations that a range of positive outcomes will result. Yet many empirically-based studies tend to find
Basterretxea, Imanol, Storey, John
core +2 more sources