Results 121 to 130 of about 2,042,267 (364)

Using Stretch Goals for Idea Generation Among Employees: One Size Does Not Fit All!

, 2021
Saeedeh Ahmadi, Justin J.P. Jansen, J. P. Eggers   +2 more
openalex   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Heterogenous Presentation of Hepatic Mucormycosis in Adults: A Case Report and Review of the Literature

Journal of Fungi
Hepatic mucormycosis is a rare but often fatal opportunistic fungal infection, primarily affecting immunocompromised patients. Herein, we report such a case from MD Anderson Cancer Center (Houston, TX, USA) and systematically review published cases in ...
Hazim Allos, Rachel S. Hicklen, Takahiro Matsuo, Javier Adachi, Sebastian Wurster, Dimitrios P. Kontoyiannis   +5 more
doaj   +1 more source

Comparative study of the effect of native architecture on planning of pond-based villages (case study: Sarakhiyeh village in the pond of Shadegan)

Cogent Engineering, 2018
The settlements are designed, built and used by people. The way of deployment and location, its growth and its changes depend on the behaviour and lifestyle of its inhabitants.
Elham Rostami, Seyed Mohammad Mousavi Shalheh   +1 more
doaj   +1 more source

China Employment Law Update - October 2018 [PDF]

, 2017
In This Issue: Various new regulations issued on Hong Kong, Taiwan and Macao residents working in mainland China Local governments ordered to slow down pursuit of unpaid and underpaid social insurance contributions New regulations issued on college and
Baker & McKenzie
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Social connections and the healthfulness of food choices in an employee population

, 2021
Douglas E. Levy, Mark C. Pachucki, A. James O’Malley, Bianca Porneala, Awesta Yaqubi, Anne N. Thorndike   +5 more
openalex   +2 more sources

Political environment, employee tenure security and firm performance in middle-income economies [PDF]

, 2023
Nicholas Addai Boamah, Francis Ofori-Yeboah, Kingsley Opoku Appiah   +2 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source