Results 81 to 90 of about 1,244,339 (308)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Role of Employment Protection During An Exogenous Shock To An Economy [PDF]
This paper explores the role of employment protection when powerful external crises reduce demand for products. We first present a theoretical framework that shows that employment protection has a U-shaped effect on abnormal unemployment during a ...
Malul Miki, Rosenboim Mosi, Shavit Tal
core
Employment protection, international specialization, and innovation [PDF]
European Economic Review, 1996 We develop a model to analyze the implications of firing costs on incentives for R & D and international specialization. The key idea is that, to avoid paying firing costs, the country with a rigid labor market will tend to produce relatively secure goods, at a late stage of their product life cycle.
openaire +7 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Employment Protection Legislation and Profits: Evidence from European Countries
Transylvanian Review of Administrative Sciences, 2012 The objective of the paper is to examine the relationship between employment protection regulations and profits in the European economies. Using regression analysis on the panel of 18 European countries over the period 1998-2008, we study the effect of ...
Suzana LAPORŠEK, Igor STUBELJ
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Employment Protection Legislation, Labour Market Dualism, and Fertility in Europe. [PDF]
Eur J Popul, 2023 Bastianelli E, Guetto R, Vignoli D.
europepmc +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Employment protection and regional self-employment rates in an economic downturn: a multilevel analysis. [PDF]
Ann Reg Sci, 2023 Filippopoulos N, Fotopoulos G.
europepmc +1 more source
Globalization and Protection of Employment [PDF]
Unionists and politicians frequently claim that globalization lowers employment protection of workers. This paper tests this hypothesis in a panel of 28 OECD countries from 1985 to 2003, differentiating between three dimensions of globalization and two ...
Fischer, Justina AV, Somogyi, Frank
core +1 more source