Results 61 to 70 of about 68,174 (219)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Ambulance traffic accidents and their impact on prehospital personnel: a mixed-methods study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Objective Prehospital personnel operate in environments with a significant risk of on-duty traffic accidents. We investigated the prevalence and characteristics of on-duty ambulance traffic accidents and explored how prehospital personnel perceive and ...
Marianne Winther, Oliver Beierholm Sørensen, Anne Craveiro Brøchner, Daniel Wittrock, Peter Martin Hansen, Jens Stubager Knudsen, Lisa Seest Nielsen, Signe Amalie Wolthers, Lars Bak Nielsen, Helle Collatz Christensen, Lotte Huniche, Søren Mikkelsen, Eva Laerkner   +12 more
doaj   +1 more source

Sustainable Ceramics: Creating Effective Key Performance Indicators for Industry Monitoring [PDF]

E3S Web of Conferences
Sustainable development in the ceramic industry focuses on meeting present needs without compromising future resources. Key strategies include recycling waste, improving energy efficiency, and adopting green technologies.
Sharma Manni, Vani V. Divya, Helena Raj J. Vijilius, Dutt Amit, Kumar J. Sunil, Almusawi Muntather, Gupta Nakul, Goyal Rajesh   +7 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Socioeconomic Disparities in Prehospital Emergency Care in a Danish Tax-Financed Healthcare System: Nationwide Cohort Study

Clinical Epidemiology, 2022
Juliane Frydenlund,1 Julie Mackenhauer,1 Erika F Christensen,2– 4 Helle Collatz Christensen,5 Ulla Væggemose,6,7 Jacob Steinmetz,8,9 Søren Paaske Johnsen1 1Department of Clinical Medicine, Aalborg University, Aalborg East, 9220, Denmark; 2Department of ...
Frydenlund J, Mackenhauer J, Christensen EF, Christensen HC, Væggemose U, Steinmetz J, Johnsen SP   +6 more
doaj  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Postural workloads on paramedics during patient transport

Current Directions in Biomedical Engineering, 2018
Paramedics perform physically demanding tasks during patient transport in daily routine and therefore suffer more often from musculoskeletal ailments, mainly low back pain, than any other profession.
Verjans Mark, Schütt Andrea, Schleer Philipp, Struck Detlef, Radermacher Klaus   +4 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Development of a Stair Climbing Mechanism for a Novel Mechatronic Transport Aid: Preliminary Results

Current Directions in Biomedical Engineering, 2018
Emergency medical service (EMS) is an essential part of health care with the main task to transport and monitor patients. However, this duty often becomes a challenge due to obstacles - especially stairs - on the way.
Schleer Philipp, Kinzius Max, Verjans Mark, Kähler Ferdinand, Radermacher Klaus   +4 more
doaj   +1 more source