Results 41 to 50 of about 363,412 (308)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

The impact of using time critical intervention‐based dispatch thresholds on lowering lights and siren use to EMS 911 incidents

open access: yesJournal of the American College of Emergency Physicians Open
Objectives Emergency Medical Services (EMS) has historically utilized lights and sirens (L&S) to respond to 911 incidents. L&S are used in 86% of scene responses nationally; however, time critical interventions (TCIs) occur in less than 7% of these ...
Jeffrey L. Jarvis   +4 more
doaj   +1 more source

Community paramedicine program and outcomes of referred coronary artery bypass grafting patients

open access: yesRural and Remote Health
Introduction: Community paramedicine is a field in its infancy. The use of community paramedics has expanded in recent years as an alternative or adjunct to home health in the continued drive to decrease health disparities and complications. In current
Regan Washist   +2 more
doaj   +1 more source

EFFECT OF ETHYL METHANE SULPHONATE ON IMPROVING THE PHYSIOLOGICAL AND BIOCHEMICAL PROPERTIES OF TWO STRAWBERRY CULTIVARS [PDF]

open access: yesمجلة الأنبار للعلوم الزراعية
A study was conducted in the laboratory of plant tissue culture in the College of Agriculture / University of Anbar to determine the effect of four concentrations of ethyl methane sulfonate (EMS) 0, 1, 2 and 3% on the biochemical characteristics of two ...
R. E. Y. AL-Hayali, S. I. Neamah
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Gamma rays and EMS induced Flower Color Mutation in Grasspea (Lathyrus sativus Linn.)

open access: yesJournal of Agricultural Sciences, 2017
To induce flower color mutants in Grasspea (Lathyrus sativus Linn.) variety “Pusa-24“, the fresh seeds were exposed to 4 different doses of gamma radiation as physical mutagens (100, 200, 300 and 400 Gy) and treated with 4 different concentration of ...
Pegah Ramezani   +3 more
doaj   +1 more source

Induced chlorophyll mutations in Gloriosa superba

open access: yesElectronic Journal of Plant Breeding, 2021
The present experiment was carried out to study the spectrum of chlorophyll mutations, mutagenic effectiveness and efficiency in Gloriosa superba seeds using both chemical and physical mutagens.
S. Padmapriya* and K. Rajamani
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Fixing for Your Life [PDF]

open access: yes
The Asian crisis took place against a background of exchange rate regimes that were characterized as soft pegs. This has led many analysts to conclude that the peg did it' and that emerging markets (EMs) should just say no' to pegged exchange rates.
Carmen M. Reinhart, Guillermo A. Calvo
core   +3 more sources

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