Results 31 to 40 of about 68,174 (219)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Altered Mental Status: Current Evidence-based Recommendations for Prehospital Care

Western Journal of Emergency Medicine, 2018
Introduction: In the United States emergency medical services (EMS) protocols vary widely across jurisdictions. We sought to develop evidence-based recommendations for the prehospital evaluation and treatment of a patient with an acute change in mental ...
Ashley Sanello, Marianne Gausche-Hill, William Mulkerin, Karl A. Sporer, John F. Brown, Kristi L. Koenig, Eric M. Rudnick, Angelo A. Salvucci, Gregory H. Gilbert   +8 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Are there study mode differences in perceptions of university education service quality? Evidence from Zambia

Cogent Business & Management, 2019
While a plethora of studies examines the relationships amongst university education service quality, customer satisfaction and loyalty, there is hardly any focus in the literature on study mode differences.
Bruce Mwiya, Beenzu Siachinji, Justice Bwalya, Shem Sikombe, Moffat Chawala, Hillary Chanda, Maidah Kayekesi, Eledy Sakala, Alexinah Muyenga, Bernadette Kaulungombe   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Hemorrhagic pseudo-cystic transformation of a sequestered lumbar disc fragment mimicking a synovial cyst

Interdisciplinary Neurosurgery
Background: Lumbar synovial cysts are most common in older adults, especially females, often associated with degenerative spine changes like facet joint arthritis and instability.
Alaa Eldin Elsharkawy, Evariste Gafumbegete, Peter Douglas Klassen   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Pre-hospital cardiac arrest: a call for moral agency in modern medical practice

BMC Medical Ethics
This article features an exemplary case of a terminally ill man with a do-not-resuscitate (DNR) order who is subject to a resuscitation attempt after suffering an out-of-hospital cardiac arrest (OHCA).
Christina Louise Joerck, Alexander Sejr Skovbo Kristensen, Martin Holdgaard Lunding, Lars Grassmé Binderup, Lotte Huniche, Mette Aaby Smith, Søren Mikkelsen, Henriette Bruun   +7 more
doaj   +1 more source