Results 31 to 40 of about 67,091 (268)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

EFFECT OF ETHYL METHANE SULPHONATE ON IMPROVING THE PHYSIOLOGICAL AND BIOCHEMICAL PROPERTIES OF TWO STRAWBERRY CULTIVARS [PDF]

open access: yesمجلة الأنبار للعلوم الزراعية
A study was conducted in the laboratory of plant tissue culture in the College of Agriculture / University of Anbar to determine the effect of four concentrations of ethyl methane sulfonate (EMS) 0, 1, 2 and 3% on the biochemical characteristics of two ...
R. E. Y. AL-Hayali, S. I. Neamah
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

The impact of using time critical intervention‐based dispatch thresholds on lowering lights and siren use to EMS 911 incidents

open access: yesJournal of the American College of Emergency Physicians Open
Objectives Emergency Medical Services (EMS) has historically utilized lights and sirens (L&S) to respond to 911 incidents. L&S are used in 86% of scene responses nationally; however, time critical interventions (TCIs) occur in less than 7% of these ...
Jeffrey L. Jarvis   +4 more
doaj   +1 more source

Community paramedicine program and outcomes of referred coronary artery bypass grafting patients

open access: yesRural and Remote Health
Introduction: Community paramedicine is a field in its infancy. The use of community paramedics has expanded in recent years as an alternative or adjunct to home health in the continued drive to decrease health disparities and complications. In current
Regan Washist   +2 more
doaj   +1 more source

Gamma rays and EMS induced Flower Color Mutation in Grasspea (Lathyrus sativus Linn.)

open access: yesJournal of Agricultural Sciences, 2017
To induce flower color mutants in Grasspea (Lathyrus sativus Linn.) variety “Pusa-24“, the fresh seeds were exposed to 4 different doses of gamma radiation as physical mutagens (100, 200, 300 and 400 Gy) and treated with 4 different concentration of ...
Pegah Ramezani   +3 more
doaj   +1 more source

Induced chlorophyll mutations in Gloriosa superba

open access: yesElectronic Journal of Plant Breeding, 2021
The present experiment was carried out to study the spectrum of chlorophyll mutations, mutagenic effectiveness and efficiency in Gloriosa superba seeds using both chemical and physical mutagens.
S. Padmapriya* and K. Rajamani
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

The Effects of EMS on the Contralateral Untrained Muscles [PDF]

open access: yes, 2018
本研究は、Cross Education 効果に着目し、これが EMS(Electrical Muscle Stimulation)による低周波電気刺激に対しても生じるかを明らかにするという目的で行った。本学の健常な男子学生10 名を対象とし、実験群として、両大腿部に EMS 機器を取り付け、右足(利き足)のみに EMS に内蔵されている電気刺激を 23 分間行う群を設けた。また、コントロール群として、実験群と同様の条件を電気刺激なしで過ごしてもらう群を設定し、それぞれ 5 名ずつ振り分けた。電気刺激を
Syusaku HORIMOTO, 堀本 秀作
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