Results 21 to 30 of about 67,091 (268)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Acute Stroke: Current Evidence-based Recommendations for Prehospital Care

Western Journal of Emergency Medicine, 2016
Introduction: In the United States, emergency medical services (EMS) protocols vary widely across jurisdictions. We sought to develop evidence-based recommendations for the prehospital evaluation and treatment of a patient with a suspected stroke and to ...
Nancy K. Glober, MD, Karl A. Sporer, MD, Kama Z. Guluma, MD, Joe A. Barger, MD, John F. Brown, MD, MPA, Gregory H. Gilbert, MD, Kristi L. Koenig, MD, Eric M. Rudnick, MD, Angelo A. Salvucci, MD   +8 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

EMS Systems: Optimised Sensor Configurations for Control and Sensor Fault Tolerance [PDF]

, 2009
The paper describes a sensor optimisation systematic framework approach and a Fault Tolerant control scheme for sensor failures applied to an EMS maglev system.
Michail, Konstantinos, Roger Goodall (1250520), Konstantinos Michail (7122557), Goodall, Roger M., Argyrios C. Zolotas (7122554), Zolotas, Argyrios   +5 more
core  

Are there study mode differences in perceptions of university education service quality? Evidence from Zambia

Cogent Business & Management, 2019
While a plethora of studies examines the relationships amongst university education service quality, customer satisfaction and loyalty, there is hardly any focus in the literature on study mode differences.
Bruce Mwiya, Beenzu Siachinji, Justice Bwalya, Shem Sikombe, Moffat Chawala, Hillary Chanda, Maidah Kayekesi, Eledy Sakala, Alexinah Muyenga, Bernadette Kaulungombe   +9 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pre-hospital cardiac arrest: a call for moral agency in modern medical practice

BMC Medical Ethics
This article features an exemplary case of a terminally ill man with a do-not-resuscitate (DNR) order who is subject to a resuscitation attempt after suffering an out-of-hospital cardiac arrest (OHCA).
Christina Louise Joerck, Alexander Sejr Skovbo Kristensen, Martin Holdgaard Lunding, Lars Grassmé Binderup, Lotte Huniche, Mette Aaby Smith, Søren Mikkelsen, Henriette Bruun   +7 more
doaj   +1 more source

Hemorrhagic pseudo-cystic transformation of a sequestered lumbar disc fragment mimicking a synovial cyst

Interdisciplinary Neurosurgery
Background: Lumbar synovial cysts are most common in older adults, especially females, often associated with degenerative spine changes like facet joint arthritis and instability.
Alaa Eldin Elsharkawy, Evariste Gafumbegete, Peter Douglas Klassen   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source