Results 191 to 200 of about 202,867 (295)

Systematic pathway‐level analysis defines conserved transcriptional divergence between primary lung tumors and cell line models

Animal Models and Experimental Medicine, EarlyView.
Lung cancer cell lines diverge substantially from primary tumors at the transcriptional level. Using single‐sample gene set enrichment analysis and L1‐penalized feature selection across TCGA‐LUAD and CCLE‐LUAD, we identified five Hallmark pathways (E2F targets, G2M checkpoint, IFNγ response, coagulation, and EMT) that discriminated primary tumors from ...
Pritam Bera, Rajesh Raju, Debodipta Das
wiley   +1 more source

Emetine and Its Derivatives as Anticancer Agents Targeting the PI3K/AKT/mTOR Pathway: A Narrative Review of Mechanisms, Pharmacology, and Clinical Insights. [PDF]

J Cell Mol Med
Khatun MI, Selim S, Malik AH, Al Hasan MS, Khalipha ABR, Yana NT, Alshahrani MY, Hossain MA, Rakib IH, Chakrabarty A, Mia E.   +10 more
europepmc   +1 more source

Ac‐SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of Ac‐SDKP regulating the FAS/FASL and mitochondrial apoptosis pathways via HSP27. Ac‐SDKP inhibits HSP27 expression, activates the FAS/FASL pathway and Caspase‐3 signaling, increases Caspase‐8 and Caspase‐3 expression, and induces cell apoptosis.
Wenxin Guo, Jinyin Yan, Wenli Li, Jin Wang, Lu Liu, Chengmei Zhang, Wei Cao, Shanshan Yao, Haibo Gong, Yi He, Zihan Zhou, Siyan Chen, Li Feng, Haijing Deng   +13 more
wiley   +1 more source

Linking EMT Dynamics to Cellular Plasticity: YAP/TAZ as Central Regulators Across Physiological and Pathological States. [PDF]

Genes (Basel)
Amicone L, Cicchini C, Petti F, Marchetti A.   +3 more
europepmc   +1 more source

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, EarlyView.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Modulators of epithelial-mesenchymal transitions in prostate cancer: potential for novel therapeutics development. [PDF]

Front Pharmacol
Zheng J, Li L, Russell H, Duzgun D, Oltean S.   +4 more
europepmc   +1 more source

The TBX18/SIX1 Transcriptional Circuit Maintains Stemness and EMT States to Promote Radioresistance in ESCC. [PDF]

Cancers (Basel)
Gu L, Yang T, Zhang J, Wu J, Fan Q, Zhang Y, Che J, Zhu J, Gu K, Zhou J.   +9 more
europepmc   +1 more source

Myofibroblastic CAF and Malignant Ductal Cell Crosstalk Drives Epithelial-Mesenchymal Transition and Progression in Pancreatic Ductal Adenocarcinoma via THBS2-SDC/Integrin Axes. [PDF]

Int J Mol Sci
Ren Z, Li Z, Wang J, Liu Y, Chen L, Su Y, Zhao L, Liu X.   +7 more
europepmc   +1 more source

SOX6 is expressed in various cell lineages in the developing mouse heart and contributes to proper valvuloseptal development

The Anatomical Record, EarlyView.
Abstract Cells derived from the endocardium, epicardium, cardiac neural crest, and second heart field play a critical role in the formation of the valvuloseptal structures of the heart. Previous studies have shown that the expression of the transcription factor SOX9 in these cell populations is essential in the regulation of this process.
Hannah G. Tarolli, Andrew B. Harvey, Inara Devji, Raymond N. Deepe, Jenna R. Drummond, Renélyn A. Wolters, Andy Wessels   +6 more
wiley   +1 more source

Epithelial-mesenchymal transition is associated with altered immune composition and cytotoxic function in triple-negative breast cancer. [PDF]

Breast Cancer Res
Lu H, Bagheri M, Kolling FW, Salas LA, Wang X, Miller TW, Pattabiraman DR, Christensen B.   +7 more
europepmc   +1 more source