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Nature Cell Biology, 2008
Epithelial-mesenchymal transition, in which epithelial cells lose their polarity and become motile mesenchymal cells, occurs during development and marks a key step in tumour progression towards metastasis. Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway ...
Levayer, Romain, Lecuit, Thomas
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Epithelial-mesenchymal transition, in which epithelial cells lose their polarity and become motile mesenchymal cells, occurs during development and marks a key step in tumour progression towards metastasis. Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway ...
Levayer, Romain, Lecuit, Thomas
openaire +3 more sources
On translational regulation and EMT
Seminars in Cancer Biology, 2012Translational regulation is increasingly recognized as a critical mediator of gene expression. It endows cells with the ability to decide when a particular protein is expressed, thereby ensuring proper and prompt cellular responses to environmental cues.
Valentina, Evdokimova +2 more
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2020
Epithelial Mesenchymal Transition (EMT) initially discovered as a key developmental mechanism is now shown to be indirectly involved in fibrosis and is contributing to the progression of carcinomas. Additionally, to transcription factors driving the morphological transition, novel mechanisms are now described to modulate the different features of the ...
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Epithelial Mesenchymal Transition (EMT) initially discovered as a key developmental mechanism is now shown to be indirectly involved in fibrosis and is contributing to the progression of carcinomas. Additionally, to transcription factors driving the morphological transition, novel mechanisms are now described to modulate the different features of the ...
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EMT in developmental morphogenesis
Cancer Letters, 2013Carcinomas, cancers of epithelial origin, constitute the majority of all cancers. Loss of epithelial characteristics is an early step in carcinoma progression. Malignant transformation and metastasis involve additional loss of cell-cycle control and gain of migratory behaviors.
Yukiko, Nakaya, Guojun, Sheng
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Science Signaling, 2014
A transcriptionally inactive p53 variant promotes mesenchymal phenotypes from the mitochondria.
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A transcriptionally inactive p53 variant promotes mesenchymal phenotypes from the mitochondria.
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2017
An open electromagnetic tracking system ...
Padraig Cantillon-Murphy +1 more
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An open electromagnetic tracking system ...
Padraig Cantillon-Murphy +1 more
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