Results 41 to 50 of about 17,797 (294)
Statistical mechanics in climate emulation: Challenges and perspectives
Environmental Data Science, 2022 Climate emulators are a powerful instrument for climate modeling, especially in terms of reducing the computational load for simulating spatiotemporal processes associated with climate systems.
Ivan Sudakow +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of Advances in Modeling Earth SystemsWe present a new additive method, referred to as sage for Simplified Additive Gaussian processes Emulator, for emulating climate model Perturbed Parameter Ensembles (PPEs).
Qingyuan Yang +3 more
doaj +1 more source
GeoHealth, 2022 Machine learning models can emulate chemical transport models, reducing computational costs and enabling more experimentation. We developed emulators to predict annual−mean fine particulate matter (PM2.5) and ozone (O3) concentrations and their ...
Luke Conibear +6 more
doaj +1 more source
A Switched Capacitor Memristor Emulator Using Stochastic Computing
Technologies, 2022 Due to the increased use of memristors and their many applications, the use of emulators has grown in parallel to avoid some of the difficulties presented by real devices, such as variability and reliability.
Carola de Benito +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Geophysical Research Letters, 2021 To improve the numerical weather prediction model over Korea using a neural network (NN) radiation emulator, two types of compound parameterization (CP) were developed.
Hwan‐Jin Song +2 more
doaj +1 more source
Statistical Emulation of Neural Simulators: Application to Neocortical L2/3 Large Basket Cells
Frontiers in Big Data, 2022 Many scientific systems are studied using computer codes that simulate the phenomena of interest. Computer simulation enables scientists to study a broad range of possible conditions, generating large quantities of data at a faster rate than the ...
Gilad Shapira +5 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
MERCURY: A Fast and Versatile Multi‐Resolution Based Global Emulator of Compound Climate Hazards
Journal of Advances in Modeling Earth SystemsHigh‐impact climate damages are often driven by compounding conditions, such as elevated heat stress arising from combined high humidity and temperatures. To explore future changes in compounding hazards under several climate scenarios, climate emulators
Shruti Nath +5 more
doaj +1 more source