Results 51 to 60 of about 13,153 (303)

A Switched Capacitor Memristor Emulator Using Stochastic Computing

open access: yesTechnologies, 2022
Due to the increased use of memristors and their many applications, the use of emulators has grown in parallel to avoid some of the difficulties presented by real devices, such as variability and reliability.
Carola de Benito   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Compound Parameterization to Improve the Accuracy of Radiation Emulator in a Numerical Weather Prediction Model

open access: yesGeophysical Research Letters, 2021
To improve the numerical weather prediction model over Korea using a neural network (NN) radiation emulator, two types of compound parameterization (CP) were developed.
Hwan‐Jin Song   +2 more
doaj   +1 more source

Statistical Emulation of Neural Simulators: Application to Neocortical L2/3 Large Basket Cells

open access: yesFrontiers in Big Data, 2022
Many scientific systems are studied using computer codes that simulate the phenomena of interest. Computer simulation enables scientists to study a broad range of possible conditions, generating large quantities of data at a faster rate than the ...
Gilad Shapira   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

A Simple Emulator That Enables Interpretation of Parameter‐Output Relationships, Applied to Two Climate Model PPEs

open access: yesJournal of Advances in Modeling Earth Systems
We present a new additive method, referred to as sage for Simplified Additive Gaussian processes Emulator, for emulating climate model Perturbed Parameter Ensembles (PPEs).
Qingyuan Yang   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Design validation of a laboratory-scale wind turbine emulator

open access: yesCogent Engineering, 2017
Presented in this study is an investigation of the real-time performance of a laboratory-scale model of wind turbine emulator. Developed to provide a cost-effective experimental facility for demonstrating and validating wind energy conversion systems at ...
Titus Oluwasuji Ajewole   +3 more
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon   +5 more
wiley   +1 more source

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