Results 121 to 130 of about 217,999 (303)

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Impact of different emulsifiers on biocompatibility and inflammatory potential of Perfluorohexyloctane (F6H8) emulsions for new intravenous drug delivery systems

Drug Design, Development and Therapy, 2019
Charalambos Tsagogiorgas,1 Friedrich Anger,1,2 Grietje Beck,1 Annette Breedijk,3 Benito Yard,3 Simone Hoeger31Department of Anaesthesiology and Critical Care Medicine, University Hospital Mannheim, Faculty of Medicine, University of Heidelberg, Mannheim,
Tsagogiorgas C, Anger F, Beck G, Breedijk A, Yard B, Hoeger S   +5 more
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Clinical study of etomidate emulsion combined with remifentanil in general anesthesia

, 2013
Digui Weng, Menghua Huang, Runnian Jiang, Rufu Zhan, Chunni YangDepartment of Anesthesiology, Mindong Hospital Affiliated to Fujian Medical University, Fuan, Fujian, People's Republic of ChinaBackground: The aim of this study was to investigate and ...
Weng D, Zhan R, Huang M, Jiang R, Yang C
core  

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Emulsion-Free 3D Printing of Inherently Porous Molecularly Imprinted Polymers with Tailored Macroscopic Geometries

Molecularly imprinted polymers (MIPs) with customizable macroscopic shapes expand the scope of molecular imprints’ impressive applications. Combining 3D printing with molecular imprinting technology enables reproducible and scalable fabrication of ...
Benedikt Keitel (18183843), Boris Mizaikoff (461404), Mehmet Dinc (18183849), Simon Schimana (18183846), Alex D. Batista (5669768)   +4 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Investigacion experimental de la prestaciones de un motor monocilíndrico usando combustible diesel emulsionado; Experimental investigation of the single cylinder engine performance using emulsified diesel fuel

Revista Científica de Ingeniería Energética, 2015
En esta investigación se realiza un análisis de las prestaciones y emisiones de un motor Petter mono-cilíndrico de inyección directa al usar como combustible una emulsión de 5% de agua, 2%de surfactante y combustible diesel.
Eliezer Ahmed Melo Espinosa, Ramón Piloto Rodriguez, Leonardo Goyos Perez, Noel Ferrer Frontela, Michel Errasti Cabrera   +4 more
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Metal‐Half‐Salen Chemistry for One‐Pot Mineralization on Hydrophobic Polymer Membranes

Advanced Science, EarlyView.
Here we report a versatile one‐pot synthetic strategy for organic–inorganic composite membranes, which leverages a metal half‐Salen system to precisely govern the competing kinetics of coordination and hydrolysis. In contrast to conventional two‐step metal‐phenol chemistries, our integrated approach substantially simplifies the fabrication process ...
Rou‐Ming Wen, Hao Ye, Ming‐Bang Wu, Lu‐Lin Ma, Qi‐Hui Ye, Zi‐Hao Yuan, Yi Xie, Juming Yao, Hao‐Cheng Yang   +8 more
wiley   +1 more source

Theory and practice of determining the rates of nucleation and droplets growth in three-component liquid mixtures with limited solubility of components

Тонкие химические технологии, 2012
The article discusses the possibility of applying the approaches of the theory of the formal analogy of processes with structural transformation of the original system for studying the dynamics of emulsions formation by supersaturation with respect to ...
Yu. A. Taran, T. I. Pynkova, A. L. Taran
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