Results 101 to 110 of about 3,133,392 (302)
Digital Transformation of Business Models — Best Practice, Enablers, and Roadmap
Digital Disruptive Innovation, 2017 The purpose of this paper is to clarify the definition of digital transformation (DT) and to introduce a structured approach with phases, activities and results.
Daniel Schallmo +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Frontiers in Public HealthIntegrated care refers to person-centered and coordinated, health and social care, and community services. Integrated care systems are partnerships of organizations that deliver health and care services which were placed on a statutory footing in England,
Linda J. M. Thomson, Helen J. Chatterjee
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Etapas en la evolución de la mejora continua: Estudio multicaso
Intangible Capital, 2014 Objeto: El modelo de evolución de la mejora continua en las empresas está en un estado intermedio de desarrollo. En investigaciones previas se han planteado y validado las etapas o niveles y los comportamientos o conductas asociadas a cada una de ellas ...
Juan A. Marin-Garcia +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Barriers and enablers of physical activity engagement for patients with COPD in primary care
International Journal of COPD, 2017 Maria-Christina Kosteli,1 Nicola R Heneghan,1 Carolyn Roskell,1 Sarah E Williams,1 Peymane Adab,2 Andrew P Dickens,2 Alexandra Enocson,2 David A Fitzmaurice,2 Kate Jolly,2 Rachel Jordan,2 Sheila Greenfield,2 Jennifer Cumming1 1School of Sport, Exercise ...
Kosteli MC +11 more
doaj
Buildings, 2019 The Architecture Engineering and Construction (AEC) sector has been working on an increasing number of mega projects having large scale investments worldwide.
Ozan Koseoglu +2 more
doaj +1 more source
Procedia CIRP, 2019 Digitalization is changing the business environment and companies face challenges to make progress. A first step to support companies is to verify their digital readiness, capabilities, and developing clear plans for improvement.
Carla Gonçalves Machado +5 more
semanticscholar +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source