Results 1 to 10 of about 2,091,453 (310)

Outer membrane vesicles: Versatile nanocarriers for therapeutic delivery and immune modulation

Acta Pharmaceutica Sinica B
Outer membrane vesicles (OMVs) are nanoscale lipid-bilayer vesicles naturally released by Gram-negative bacteria. By packaging membrane proteins, lipopolysaccharide-derived pathogen-associated molecular patterns, nucleic acids, and metabolites, OMVs ...
Jinlong Yang, Tang Wang, Yuekai Zheng, Yuning Wei, Juan Tao, Zhongjian Chen, Jianping Qi   +6 more
doaj   +1 more source

Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR

Pharmaceutics, 2020
Passive immunotherapy, i.e., treatment with therapeutic antibodies, has been increasingly used over the last decade in several diseases such as cancers or inflammation.
Elodie Pothin, Dominique Lesuisse, Pierre Lafaye   +2 more
doaj   +1 more source

Head‐to‐head comparison between ACQ and FRET in probing polymeric micelles

View
Environmentally responsive fluorophores, such as those with aggregation‐caused quenching (ACQ) and Förster resonance energy transfer (FRET) properties, are widely used to track nanocarriers while minimizing artifacts.
Runtong Zhang, Chang Liu, Ruonan Lu, Yuanmei Yang, Zichen Zhang, Yifan Cai, Haisheng He, Yi Lu, Aun Raza, Wei Wu   +9 more
doaj   +1 more source

Biomimetic liposomes synergize with high-intensity focused ultrasound to induce ferroptosis in tumors

Acta Pharmaceutica Sinica B
The efficient targeted delivery and on-demand release of nanomedicines still present significant challenges in tumor therapy. In the present study, we developed a novel strategy of tumor ferroptosis therapy through the synergistic effect of nanomedicines
Ruizhe Xu, Xuejing Li, Xiaomin Su, Xifeng Qin, Ying He, Siyu Wang, Yue Liu, Jiayi Wu, Ting Wang, Mingyang Liu, Boshu Ouyang, Jia Li, Wuli Yang, Bo Zhang, Zhiqing Pang   +14 more
doaj   +1 more source

TrkB-enhancer facilitates functional recovery after traumatic brain injury

Scientific Reports, 2017
Brain-derived neurotrophic factor (BDNF), a key player in regulating synaptic strength and learning, is dysregulated following traumatic brain injury (TBI), suggesting that stimulation of BDNF signaling pathways may facilitate functional recovery.
John Marshall, Joanna Szmydynger-Chodobska, Mengia S. Rioult-Pedotti, Kara Lau, Andrea T. Chin, Siva K. Reddy Kotla, Rakesh Kumar Tiwari, Keykavous Parang, Steven W. Threlkeld, Adam Chodobski   +9 more
doaj   +1 more source

Intratympanic dexamethasone microcrystals/lidocaine‐loaded PLGA non‐spherical microparticles for local drug delivery to the inner ear

Animal Models and Experimental Medicine
Background Sudden sensorineural hearing loss (SSNHL), often associated with tinnitus, significantly impacts individuals' quality of life. Current treatments, such as free drugs via intravenous or intratympanic (IT) administration of dexamethasone (DEX ...
Dongcheng Wang, Xin Zhang, Zhen Wang, Cheng Ran, Jia Hao, Xiaobo Ma, Minghui Wang, Zhimin Zhou   +7 more
doaj   +1 more source

Fluorescence bioimaging of drug nanocarriers based on Förster resonance energy transfer, aggregation-induced emission and aggregation-caused quenching

Acta Pharmaceutica Sinica B
The introduction of environment-responsive probes has greatly improved the accuracy of fluorescence bioimaging in evaluating drug nanocarriers. This review highlights the key roles of Förster resonance energy transfer, aggregation-induced emission, and ...
Runtong Zhang, Haisheng He, Yi Lu, Aun Raza, Wei Wu   +4 more
doaj   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics & Systems Pharmacology
Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two ...
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
doaj   +1 more source

Fused Membrane-Targeted Nanoscale Gene Delivery System Based on an Asymmetric Membrane Structure for Ischemic Stroke

Pharmaceutics
Background: Bone marrow-derived mesenchymal stem cell exosomes (EXOs) are attractive in biotechnology and biomedical research, as they possess natural cell-targeting properties and can cross biological barriers by influencing the SDF-1/CXCR4 axis.
Jing Shi, Xinyi Zhao, Yue Zhang, Zitong Zhao, Jing Wang, Jia Mi, Zhaowei Xu, Chunhua Yang, Jing Qin, Hong Zhang   +9 more
doaj   +1 more source

Mitochondrial targeted prodrug nanoparticles for chemo-photodynamic combinational tumour therapy

Smart Materials in Medicine
Prodrug nanoparticles have been explored as an effective means for drug delivery because of controlled drug release in a stimulus-responsive manner. Organellar-targeted drug delivery could enhance the efficacy of cancer therapy. Herein, pH and light dual
Rong Xu, Encan Zhu, Xiaoyun Lan, Qihang Yang, Chuangnian Zhang   +4 more
doaj   +1 more source