Results 1 to 10 of about 985,118 (269)
Frontiers in Immunology, 2023 Microglia, the resident macrophages of the central nervous system (CNS), play a critical role in CNS homeostasis and neuroinflammation. Pexidartinib (PLX3397), a colony-stimulating factor 1 (CSF1) receptor inhibitor, is widely used to deplete microglia ...
Wouter Claeys +26 more
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Retromer-Mediated Trafficking of Transmembrane Receptors and Transporters
Membranes, 2015 Transport between the endoplasmatic reticulum, the Golgi-network, the endo-lysosomal system and the cell surface can be categorized as anterograde or retrograde, describing traffic that goes forward or backward, respectively.
Stine C. Klinger +2 more
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The Question of Analyzing System Safety with Consideration to Human Factor [PDF]
International Journal of Mathematical, Engineering and Management Sciences, 2021 This article presents the research results of the human factor effect on system safety. The authors used historical data on inductive reasoning to obtain the results. The article shows that there is no good reason to believe that there is no human factor
Iosif Z. Aronov +2 more
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Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases
Fluids and Barriers of the CNS, 2019 The fine balance between the secretion, composition, volume and turnover of cerebrospinal fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance can be disrupted.
Steven William Bothwell +2 more
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Effects of fasudil on blood–brain barrier integrity
Fluids and Barriers of the CNS, 2022 Background Cerebral infarction accounts for 85% of all stroke cases. Even in an era of rapid and effective recanalization using an intravascular approach, the majority of patients have poor functional outcomes.
Kei Sato +12 more
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Biology, 2023 Alzheimer’s’ disease (AD) is characterized by the formation of β-amyloid (Aβ) plaques and neurofibrillary tangles of tau protein in the brain. Aβ plaques are formed by the cleavage of the β-amyloid precursor protein (APP).
Kasper Hobin +4 more
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Barriers to Entry: Abolishing the Barriers to Understanding [PDF]
Journal of Public Finance and Public Choice, 2009 The concept of a barrier to entry has been discussed least since Bain [1956] with important contributions by Spence [1977], Dixit [1980] and Milgrom - Roberts [1982]. The more recent discussion is synthesized in the contributions to a dedicated session at the 2004 AEA meeting. Yet, a ‘barrier to entry’ remains a surprisingly elusive concept, which even
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Sensors, 2021 Patients with neurological impairments often experience physical deconditioning, resulting in reduced fitness and health. Powered exoskeleton training may be a successful method to combat physical deconditioning and its comorbidities, providing patients ...
Damien Duddy +5 more
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Why Barriers to Entry Are Barriers to Understanding [PDF]
American Economic Review, 2004 This paper discusses and criticizes the usual definitions of barriers to entry. The failure of the concept of barrier to entry to incorporate a time dimension means that it is a concept that is in need of additional embellishment in order to be useful in a practical problem or for antitrust or regulatory proceedings.
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Methodological and analytical considerations for intra-operative microdialysis
Fluids and Barriers of the CNS, 2023 Background Microdialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in primary malignant brain tumors known as gliomas.
Cecile Riviere-Cazaux +12 more
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