Results 31 to 40 of about 985,118 (269)

Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis

BMC Medicine
Background Prediabetes refers to the transitional stage from normal glucose metabolism to diabetes. The International Diabetes Federation guidelines reported that, as of 2024, approximately 1.12 billion people globally were in the prediabetes stage ...
Yike Wu, Zihan Wang, Adili Tuersun, Qiuxia Yu, Yu Zhong, Shah Syed Alfakhar Ali, Haiyang Liu, Xinyi Hu, Yanfei Zhang, Liyuan Pang, Longzhou Li, Long Gao, Qiwen Wu, Shan Wang, Meng Cui, Linglu Sun, Yulin Wu, Antong Yin, Lei Zhang, Guo Ma   +19 more
doaj   +1 more source

Detecting community change in Arctic marine ecosystems using the temporal dynamics of environmental DNA

Environmental DNA, 2021
Large‐scale biomonitoring of Arctic coastal marine communities is essential to track temporal changes in ecosystems. Despite the potential of environmental DNA (eDNA) as an innovative coastal biomonitoring tool, important questions remain pertaining to ...
Maelle Sevellec, Anaïs Lacoursière‐Roussel, Louis Bernatchez, Eric Normandeau, Eric Solomon, Andrew Arreak, LeeAnn Fishback, Kimberly Howland   +7 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

PepH3-modified nanocarriers for delivery of therapeutics across the blood-brain barrier

Fluids and Barriers of the CNS
Background Nanocarriers targeting the blood-brain barrier (BBB) are promising drug delivery systems to enhance the penetration of therapeutic molecules into the brain.
Anikó Szecskó, Mária Mészáros, Beatriz Simões, Marco Cavaco, Catarina Chaparro, Gergő Porkoláb, Miguel A.R.B. Castanho, Mária A. Deli, Vera Neves, Szilvia Veszelka   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Application of Chow Test to Estimate the Effect of Mutual Recognition Agreements [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2019
This article presents the research results on Mutual Recognition Agreement effect on the volume of exports – imports of the countries (parties) in the context of the EU – Israel Mutual Recognition Agreement.
Iosif Z. Aronov, Anna M. Rybakova, Vladimir Yu. Salamatov, Anna V. Tangaeva, Nataliia M. Galkina   +4 more
doaj   +1 more source

MAP Kinase Pathways in Brain Endothelial Cells and Crosstalk with Pericytes and Astrocytes Mediate Contrast-Induced Blood–Brain Barrier Disruption

Pharmaceutics, 2021
Neurointervention with contrast media (CM) has rapidly increased, but the impact of CM extravasation and the related side effects remain controversial. This study investigated the effect of CM on blood–brain barrier (BBB) integrity.
Yuki Matsunaga, Shinsuke Nakagawa, Yoichi Morofuji, Shinya Dohgu, Daisuke Watanabe, Nobutaka Horie, Tsuyoshi Izumo, Masami Niwa, Fruzsina R. Walter, Ana Raquel Santa-Maria, Maria A. Deli, Takayuki Matsuo   +11 more
doaj   +1 more source