Results 181 to 190 of about 34,637 (221)

Epithelial Sodium Channels (ENaCs)

2015
Amiloride-sensitive epithelial sodium (Na+) channels (ENaCs) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of ...
Chang Song, He-Ping Ma, Douglas C. Eaton
openaire   +1 more source

ENaC Modulators and Renal Disease

Current Molecular Pharmacology, 2013
The epithelial sodium channel (ENaC) plays an essential role in transepithelial sodium reabsorption in the renal connecting tubule and collecting duct. Therefore, controlling ENaC activity is an important regulatory event in electrolyte and extracellular volume homeostasis, and thus in the control of blood pressure.
Diego, Alvarez de la Rosa, Juan F, Navarro-González, Teresa, Giraldez   +2 more
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Control of ENaC ubiquitination

American Journal of Physiology-Renal Physiology
We have explored the mechanisms underlying the ubiquitination of the γ subunit of epithelial Na+ channel (ENaC), a process believed to control channel internalization and degradation. We previously reported that the mature, cleaved form of the subunit is selectively ubiquitinated.
Shujie Shi, Gustavo Frindt, Sarah Christine M. Whelan, Lawrence G. Palmer   +3 more
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Inhibiting ENaC Activation

Science Signaling, 2008
Proteolytic activation of epithelial sodium channels is inhibited by increased intracellular sodium.
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Nongenomic regulation of ENaC by aldosterone

American Journal of Physiology-Cell Physiology, 2001
Aldosterone is involved in salt and water homeostasis. The main effect is thought to involve genomic mechanisms. However, the existence of plasma membrane steroid receptors has been postulated. We used whole cell patch clamp to test the hypothesis that epithelial sodium channels (ENaC) expressed by renal collecting duct principal cells can be regulated
Z H, Zhou, J K, Bubien
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ENaC proteins contribute to VSMC migration

American Journal of Physiology-Heart and Circulatory Physiology, 2006
Vascular smooth muscle cell (VSMC) migration plays a key role in tissue repair after arterial wall injury. VSMC migration requires integration of chemical and mechanical signaling mechanisms. Recently, we showed that epithelial Na+channel (ENaC) proteins are expressed in VSMCs and that ENaC inhibition abolishes pressure-induced constriction in isolated
Samira C, Grifoni, Kimberly P, Gannon, David E, Stec, Heather A, Drummond   +3 more
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Inhibition of ENaC by intracellular Cl⁻in an MDCK clone with high ENaC expression

American Journal of Physiology-Renal Physiology, 2004
We examined the effects of intracellular Cl−concentration ([Cl−]i) on the epithelial Na channel (ENaC) in a line of Madin-Darby canine kidney (MDCK) cells (FL-MDCK) with a high rate of Na+transport produced by stable retroviral transfection with rENaC subunits (Morris RG and Schafer JA. J Gen Physiol 120: 71–85, 2002). Treatment with cAMP (100 μM 8-cpt-
Yi, Xie, James A, Schafer
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Kinases as Targets for ENaC Regulation

Current Molecular Pharmacology, 2013
Amiloride-sensitive epithelial sodium channels (ENaCs) transport Na+ and are essential for salt and fluid homeostasis across epithelial tissues. Several pathological conditions of renal and pulmonary tissues are associated with abnormal ENaC function. The signalling pathways that regulate ENaC activity utilise a number of kinases.
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ENaC Channels

2023
Mike Althaus, Diego Alvarez de la Rosa, Martin Fronius   +2 more
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???????????????????? ?????????????????????? ?????????????????? ?????????????????????????? ???????????????????? ???????????????????????????? ???????????????????? ???????????? (ENaC) ?? ????????????????????????????-???????????????????????? ????????????-1 (SGK-1) ?? ?????????????? ???????????????? ?????????????? ??????????

2021
?????????????? ???? ?????? ???????? ????????????????, ?????? ?????????????? ???????? ?????????? ?????????????????????? ENaC ?? ???????????? SGK-1 ?? ?????????? 10-?????????????? ???????? ????????, ?????? ?? ???????????????? ???????????????? (??
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