The epithelial sodium channel in inflammation and blood pressure modulation [PDF]
Frontiers in Cardiovascular Medicine, 2023 A major regulator of blood pressure and volume homeostasis in the kidney is the epithelial sodium channel (ENaC). ENaC is composed of alpha(α)/beta(β)/gamma(γ) or delta(δ)/beta(β)/gamma(γ) subunits.
Taseer Ahmad +7 more
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Role of epithelial sodium channel-related inflammation in human diseases [PDF]
Frontiers in Immunology, 2023 The epithelial sodium channel (ENaC) is a heterotrimer and is widely distributed throughout the kidneys, blood vessels, lungs, colons, and many other organs.
Yabin Chen +11 more
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Metformin Alleviates Diabetes-Associated Hypertension by Attenuating the Renal Epithelial Sodium Channel [PDF]
Biomedicines, 2023 Diabetic nephropathy is the primary cause of morbidity in type 2 diabetes mellitus (T2DM) patients. New data indicate that hypertension, a common comorbidity in T2DM, can worsen outcomes of diabetic nephropathy.
Yogesh M. Scindia +11 more
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Epithelial Sodium Channel Alpha Subunit (αENaC) Is Associated with Inverse Salt Sensitivity of Blood Pressure [PDF]
Biomedicines, 2022 Salt sensitivity of blood pressure (BP) refers to an increase in BP following an increase in dietary salt, which is associated with increased incidence of cardiovascular disease and early death.
Peng Xu +8 more
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Iron Inhibits the Translation and Activity of the Renal Epithelial Sodium Channel [PDF]
Biology, 2022 Hypertension is associated with an increased renal expression and activity of the epithelial sodium channel (ENaC) and iron deficiency. Distal tubules absorb iron, causing perturbations that may influence local responses.
Abdel A. Alli +8 more
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Epithelial Sodium Channel Inhibition by Amiloride Addressed with THz Spectroscopy and Molecular Modeling [PDF]
Molecules, 2022 THz spectroscopy is important for the study of ion channels because it directly addresses the low frequency collective motions relevant for their function. Here we used THz spectroscopy to investigate the inhibition of the epithelial sodium channel (ENaC)
Maria Mernea +7 more
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Molecular principles of assembly, activation, and inhibition in epithelial sodium channel [PDF]
eLife, 2020 The molecular bases of heteromeric assembly and link between Na+ self-inhibition and protease-sensitivity in epithelial sodium channels (ENaCs) are not fully understood.
Sigrid Noreng +4 more
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Frontiers in Physiology, 2021 The activity of the Epithelial Na+ Channel (ENaC) in renal principal cells (PC) fine-tunes sodium excretion and consequently, affects blood pressure.
Antonio G. Soares +7 more
doaj +1 more source
Reduced expression of Enac in Placenta tissues of patients with severe preeclampsia is related to compromised trophoblastic cell migration and invasion during pregnancy. [PDF]
PLoS ONE, 2013 The purpose of the study is to investigate the expression of epithelial sodium channel (ENaC) in normal pregnancy and severe preeclampsia placenta and to explore the underlying mechanism of the relationship between the altered ENaC expression and onset ...
Shan Wang +7 more
doaj +1 more source
Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC
Molecular Brain, 2019 This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β-ENaC subunits showed overlapping expression with endogenous Cav3.2 calcium channels in the thalamus and hypothalamus as detected ...
Agustin Garcia-Caballero +7 more
doaj +1 more source