Results 21 to 30 of about 71,499 (299)

Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundDuring high sodium intake, the renin‐angiotensin‐aldosterone system is downregulated and nitric oxide signaling is upregulated in order to remain in sodium balance.
Kelly A. Hyndman, Elena V. Mironova, Jorge F. Giani, Courtney Dugas, Jessika Collins, Alicia A. McDonough, James D. Stockand, Jennifer S. Pollock   +7 more
doaj   +1 more source

A novel nonsense mutation in the β-subunit of the epithelial sodium channel causing Liddle syndrome

Blood Pressure, 2021
Purpose Liddle syndrome is a hereditary form of arterial hypertension caused by mutations in the genes coding of the epithelial sodium channel – SCNN1A, SCNN1B and SCNN1G.
Štěpán Mareš, Jan Filipovský, Kateřina Vlková, Martin Pešta, Václava Černá, Jaroslav Hrabák, Jitka Mlíková Seidlerová, Otto Mayer   +7 more
doaj   +1 more source

Effect of kokumi taste-active γ-glutamyl peptides on amiloride-sensitive epithelial Na+ channels in rat fungiform taste cells

Biochemistry and Biophysics Reports, 2023
Kokumi taste-active compounds enhance salty taste perception. In animal models, sodium (salt) detection is mediated by the amiloride-sensitive epithelial sodium channel, ENaC.
Albertino Bigiani, MeeRa Rhyu
doaj   +1 more source

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
King, Brian F., Wildman, Scott S.P.
core   +1 more source

Epithelial Sodium Channel [PDF]

Hypertension, 2008
Despite large changes in water and salt intake, the kidney is able to maintain the extracellular osmolarity and volume within narrow margins.1 Such fine control requires specific factors or hormones; among them, aldosterone and vasopressin play key roles.
Rossier BC, Schild L
openaire   +3 more sources

Prostasin: An Epithelial Sodium Channel Regulator [PDF]

Journal of Biomarkers, 2013
Prostasin is a glycophosphatidylinositol-anchored protein which is found in prostate gland, kidney, bronchi, colon, liver, lung, pancreas, and salivary glands. It is a serine protease with trypsin-like substrate specificity which was first purified from seminal fluid in 1994. In the last decade, its diverse roles in various biological and physiological
Shakti Aggarwal, Pradeep K. Dabla, Sarika Arora   +2 more
openaire   +2 more sources

Sodium channels and mammalian sensory mechanotransduction

Molecular Pain, 2012
Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin, Rugiero Francois, Kiesewetter Hannes, Hatch Rachel, Hummler Edith, Nassar Mohammed A, Wang Fan, Wood John N   +7 more
doaj   +1 more source

Epithelial Barrier Dysfunction in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) via Downregulation of Claudin-1

Cells, 2023
Background: In patients with diarrhea-predominant irritable bowel syndrome (IBS-D), the diarrheal mechanisms are largely unknown, and they were examined in this study on colon biopsies.
Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Jörg-Dieter Schulzke, Roland Bücker   +7 more
doaj   +1 more source

Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance [PDF]

, 2014
Aldosterone promotes electrogenic sodium reabsorption through the amiloride-sensitive epithelial sodium channel (ENaC). Here, we investigated the importance of ENaC and its positive regulator channel-activating protease 1 (CAP1/Prss8) in colon.
Charles, R.P., Perrier, R., Wang, Q., Wang, Qing, Sergi, C., Hummler, Edith, Hummler, E., Malsure, Sumedha, Malsure, S., Charles, Roch-Philippe, Perrier, Romain, Christensen, B.M., Rossier, Bernard C, Maillard, Marc, Christensen, Birgitte Mønster, Rossier, B.C., Maillard, M., Sergi, Chloe   +17 more
core   +1 more source

Epithelial sodium channel regulatory proteins identified by functional expression cloning [PDF]

, 1998
Epithelial sodium channel regulatory proteins identified by functional expression cloning. We describe here our current strategy for identifying and cloning proteins involved in the regulation of the epithelial sodium channel (ENaC).
Rossier, Bernard C., Vallet, Véronique, Horisberger, Jean-Daniel   +2 more
core   +3 more sources